Global DNA Read, Write and Edit Market
The scope of the report includes DNA read, write and edit technologies, applications, industries, initiatives, patents and companies. The markets for read, write and edit products and services are given for 2017, 2018, 2019 (estimated) and 2024 (forecast).
This report reviews the main read, write and edit technologies and explains why genetic variation is important in clinical testing and disease. It then discusses significant large-scale research initiatives that impact read, write and edit applications. Of particular interest is a discussion of population-scale sequencing projects throughout the world, and their likely impact. The main market driving forces for read, write and edit products and services are listed and discussed.
The report quantifies each of the main market segments. The read (sequencing) market is quantified by delivered format, including sequencing workflow products (sample preparation kits and reagents, sequencing instruments and consumables, and informatics) and sequencing services (clinical diagnostics and sequencing services to applied market customers).
The sequencing workflow products market is quantified by type, that is, DNA isolation and extraction; target enrichment; library preparation; and informatics/ecosystems. The sequencing instruments and consumables market is given by platform (Sanger, NGS and 3GS).
The sequencing services market is analyzed by end user application (applied, clinical, and R&D). Within sequencing services, the applied market is analyzed by end-user application (agriculture, biopharma, consumer, microbiology, population-scale genomics, synthetic biology and other).
Also within sequencing services, the clinical market is analyzed and quantified by disease category (cardiovascular, clinical microbiology and infectious diseases, Mendelian disorders, metabolic/immune disorders, neurology, oncology, reproductive health and transplant medicine).
The DNA write (synthesis) market is quantified by product type (oligonucleotides, synthetic biology parts, genes and RNA therapeutics). The oligonucleotide market is analyzed by application (gene editing, sequencing, PCR, FISH, microarray, gene synthesis and other). The gene market is quantified by gene type (standardized, value-added). Finally, the RNA therapeutics market is quantified by platform (RNA interference, antisense oligos, micro RNA modulation and mRNA) and by disease category (cancer, hematology, musculoskeletal, neurology and rare diseases).
The DNA edit (gene editing) market is quantified by application (agriculture, biopharma, diagnostics and therapeutics); editing platform (CRISPR, meganuclease, TALEN, ZFN). The gene editing agriculture market is analyzed by product type (crop/seeds, livestock). The gene editing biotechnology market is analyzed by product type (kits and reagents, cell line engineering, animal models and services). The gene editing therapeutics market is analyzed by disease category (eye and rare diseases).
Specific geographic markets discussed include North America, Europe, Asia-Pacific, and the rest of the world (ROW).
Industry sectors analyzed include next-generation sequencing; long read sequencing; DNA synthesis; RNA therapies; and gene editing.
More than 320 companies in the read, write and edit industry are profiled in this report.
It also provides a summary of more than 180 of the main industry acquisitions and strategic alliances that took place from January 2018 through June 2019, including key alliance trends.
- 28 data tables and 77 additional tables
- An overview of the global market for DNA read, write and edit technologies, applications, and industries
- Analyses of global market trends, with market data from 2017, 2018, estimates for 2019, and projections of compound annual growth rates (CAGRs) through 2024
- Discussion on sequencing technologies, market applications, industry structure, and important clinical sequencing initiatives
- Information pertaining to several significant large-scale research initiatives that are contributing to sequencing services, write synthesis and gene editing technologies market development
- A look at the innovations in pharmaceutical and biotechnology companies and research & development programs in stem cell-based therapies and gene therapies
- Coverage of significant patents and their allotments in each category, as well as major industry acquisitions and strategic alliances data
- Company profiles of over 320 major global players within the industry, including 3Billion Inc., 23Andme Inc., Bayer AG, Becton, Dickinson and Co. (BD), Bio-Rad Laboratories, Pacific Biosciences, Qiagen NV, Roche Holding AG and Thermo Fisher Scientific Inc.
Chapter 1 Introduction
Study Goals and Objectives
Reasons for Doing the Study
Scope of Report
BCC Custom Research
Related BCC Research Reports
Chapter 2 Summary and Highlights
Chapter 3 Overview
DNA Read, Write and Edit Technologies and Markets
Large-Scale Initiatives and Consortia
Applications of DNA Read, Write and Edit Technologies
DNA Read, Write and Edit Market Driving Forces
Global DNA Read, Write and Edit Markets
Chapter 4 Technology Background
Introduction to Nucleic Acid Technologies
Genetic Variation and Analysis
DNA Write (Synthesis) Technologies
Gene Editing Technologies
CRISPR Enzyme Technologies
Gene Editing Delivery Technologies
Viral Delivery Technologies
Non-Viral Delivery Technologies
Chapter 5 DNA Read, Write and Edit Initiatives
American Gut Consortium
Blood Profiling Atlas
Cancer Moon Shots Program
China Precision Medicine Initiative
Clinical Genome Resource
Epigenetics for Females Personalized Cancer Care
France Genomic Medicine Plan
Friends of Cancer Research Project
Gene Therapy Initiative
Human Cell Atlas Consortium
Integration of Imaging and Fluid-based Tumor Monitoring in Cancer Therapy Program
Laboratory for Genomics Research
Liquid Biopsies and Imaging for Improved Cancer Care
Lung Cancer Master Protocol Project
Medical Genome Initiative
Metagenomics and Metadesign of Subways and Urban Biomes
Million Veteran Program
Molecular Integration in Neurological Diagnosis
National Microbiome Initiative
Next-generation Single Cell Analysis Program
Precision Medicine Initiative
Prospective Registry of Multiple Testing
Quality Assurance Initiative Pathology Project
Somatic Cell Genome Editing Program
Trans Omics for Precision Medicine Initiative
Population Sequencing Programs
Chapter 6 DNA Read, Write and Edit Applications
Genome Editing Applications
DNA Sequencing Applications
DNA Write (Synthesis) Applications
BioBrick (Synbio) Parts
Genome Editing Applications
Screening and Tools
Chapter 7 DNA Read, Write and Edit Industries
Sequencing Instruments Industry
Long Read Sequencing Industry
DNA Write (Synthesis) Industry
Oligos as Therapeutics
Gene Synthesis Workflow
Gene Synthesis Value Chain
Synthetic Gene Market Segments
Gene Editing Industry
Chapter 8 Acquisitions and Strategic Alliances
Chapter 9 DNA Read, Write and Edit Markets
Industry Growth-Driving Forces
DNA Read, Write and Edit Technologies
Global DNA Read (Sequencing), Write (Synthesis) and Edit (Gene Edit) Markets
DNA Read (Sequencing) Markets
Clinical Diagnostic Sequencing Market
DNA Write (Synthesis) Markets
Gene Editing Market
Market for Gene-edited Crops/Seeds
Gene-edited Livestock Market
Chapter 10 Patents
Circulating Tumor Cell Patents
Cell-free DNA Patents
Sequencing-related Patent Issues
Gene Editing-Related Patents
Gene Editing Patents (Sangamo Case Study)
RNA Therapy-related Patents
Chapter 11 Nucleic Acid Read, Write and Edit Company Profiles
10X GENOMICS INC.
ADAPTIVE BIOTECHNOLOGIES INC.
AGILENT TECHNOLOGIES INC.
AJINOMOTO CO., INC.
ALLOGENE THERAPEUTICS INC.
ALMAC GROUP LTD.
AMARANTUS BIOSCIENCE HOLDINGS INC.
ANCHORDX MEDICAL CO., LTD.
ANNOROAD GENE TECHNOLOGY CO., LTD.
ANSA BIOTECHNOLOGIES INC.
APEIRON BIOLOGICS AG
ARBOR BIOTECHNOLOGIES INC.
ARCADIA BIOSCIENCES INC.
ARCTURUS THERAPEUTICS INC.
ASIA GENOMICS PTE. LTD.
ASTRIDBIO TECHNOLOGIES KFT.
ATG BIOSYNTHETICS GMBH
ATHENA DIAGNOSTICS INC.
BASE4 INNOVATION LTD.
BEAM THERAPEUTICS INC.
BECTON, DICKINSON AND CO.
BENSON HILL BIOSYSTEMS INC.
BERRY GENOMICS CO., LTD.
BIO BASIC INC.
BIO-RAD LABORATORIES INC.
BIO S&T INC.
BLUE HERON BIOTECH LLC
BLUESTAR GENOMICS INC.
B-MOGEN BIOTECHNOLOGIES INC.
BRISTOL-MYERS SQUIBB CO.
BROOKS LIFE SCIENCES
CAMBRIDGE EPIGENETIX LTD.
CARIS LIFE SCIENCES
CARIBOU BIOSCIENCES INC.
CATALOG TECHNOLOGIES INC.
COFACTOR GENOMICS INC.
CORIELL LIFE SCIENCES INC.
CRISPR THERAPEUTICS AG
CYGNUS BIOSCIENCES CO., LTD.
DARUI BIOTECHNOLOGY CO., LTD.
DATAR CANCER GENETICS LTD.
DESKTOP GENETICS LTD.
DIRECTED GENOMICS LLC
DIRECT GENOMICS CO., LTD.
DNA ELECTRONICS LTD.
DOVETAIL GENOMICS LLC
EDITAS MEDICINE INC.
EPIC SCIENCES INC.
EPOCH LIFE SCIENCE INC.
EXACT SCIENCES CORP.
EZLIFE BIO INC.
FLUXION BIOSCIENCES INC.
FRY LABORATORIES LLC
FULL GENOMES CORP.
FUSION GENOMICS CORP.
G+FLAS LIFE SCIENCES INC.
GENE BY GENE LTD.
GENEMED SYNTHESIS INC.
GENERAY BIOTECH CO., LTD.
GENETICS RESEARCH LLC
GENOMATIX SOFTWARE GMBH
GENOME. ONE PTY LTD.
GENOMIC HEALTH INC.
GENOME PROFILING LLC
GENEXOSOME TECHNOLOGIES INC.
GILEAD SCIENCES INC.
GRANDOMICS BIOSCIENCES CO., LTD.
GUARDANT HEALTH INC.
HELIX OPCO LLC
HELIXWORKS TECHNOLOGIES LTD.
HORIZON DISCOVERY GROUP PLC
HTG MOLECULAR DIAGNOSTICS INC.
HOMOLOGY MEDICINES INC.
HUMAN LONGEVITY INC.
INEX INNOVATIONS EXCHANGE PTE. LTD.
INTELLIA THERAPEUTICS INC.
INTERPACE DIAGNOSTICS LLC
KANEKA EUROGENTEC S.A.
KINGMED DIAGNOSTICS CENTER CO., LTD.
KWS SAAT SE
LABORATORY CORP. OF AMERICA INC.
LABORATORY FOR MOLECULAR MEDICINE
LEUCINE RICH BIO PVT. LTD.
LEXENT BIO INC.
LUNGLIFE AI, INC.
MAYO MEDICAL LABORATORIES
MEDGENOME LABS PVT. LTD.
MENARINI SILICON BIOSYSTEMS SPA
MOLECULAR ASSEMBLIES INC.
MOLECULAR HEALTH GMBH
MOLECULAR LOOP BIOSOLUTIONS LLC
MYRIAD GENETICS, INC.
NANOSTRING TECHNOLOGIES INC.
NEW ENGLAND BIOLABS
NEW ONCOLOGY GMBH
NGENEBIO CO., LTD.
NOVARTIS PHARMA AG
NOVOGENE CO., LTD.
NUCLERA NUCLEICS LTD.
NUGEN TECHNOLOGIES INC.
NX PRENATAL INC.
OCUNEXUS THERAPEUTICS INC.
OMEGA BIO-TEK INC.
OXFORD BIOMEDICA PLC
OXFORD GENETICS LTD.
OXFORD NANOPORE TECHNOLOGIES LTD.
PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
PAIRWISE PLANTS INC.
PARADIGM DIAGNOSTICS INC.
PARSEQ LAB CO., LTD.
PATHWAY GENOMICS CORP.
PERSONAL GENOME DIAGNOSTICS INC.
PHIO PHARMACEUTICALS CORP.
POPULATION GENETICS TECHNOLOGIES LTD.
PORTABLE GENOMICS LLC
POSEIDA THERAPEUTICS INC.
PRECISION BIOSCIENCES INC.
QUANTUM BIOSYSTEMS INC.
QUEST DIAGNOSTICS INC.
REAL-TIME GENOMICS INC.
RESOLUTION BIOSCIENCE INC.
ROCHE HOLDING AG
SANGAMO THERAPEUTICS INC.
SAREPTA THERAPEUTICS INC.
SEVEN BRIDGES GENOMICS INC.
SHINEGENE MOLECULAR BIO-TECHNOLOGIES INC.
SIGMA ALDRICH CORP.
SINGLERA GENOMICS INC.
SISTEMAS GENMICOS SL
STA PHARMACEUTICAL CO., LTD.
STRAND LIFE SCIENCES PVT. LTD.
STRATOS GENOMICS INC.
SUPRATECH MICROPATH LABORATORY & RESEARCH INSTITUTE PVT. LTD.
SYNBIO TECHNOLOGIES INC.
SYNTHETIC GENOMICS INC.
THERANOSIS LIFE SCIENCES PVT. LTD.
THERMO FISHER SCIENTIFIC INC.
THRIVE EARLY DETECTION CORP.
TRACE GENOMICS INC.
TROPIC BIOSCIENCES UK LTD.
UBIQUITY GENOMICS INC.
VIR BIOTECHNOLOGY INC.
XING TECHNOLOGIES LLC
YIELD10 BIOSCIENCES INC.
YIKON GENOMICS CO., LTD.
YOURGENE HEALTH PLC
ZHEJIANG DIAN DIAGNOSTICS CO., LTD.
List Of Tables
Summary Table : Global Market for DNA Read, Write and Edit, by Application, Through 2024
Table 1 : Report Scope
Table 2 : Impact of Large-scale Initiatives on the Read, Write and Edit Industry
Table 3 : Life Cycle Status of Applications for Read, Write and Edit Technologies
Table 4 : Driving Forces of DNA Read, Write and Edit Industry Growth
Table 5 : Global Market for DNA Read, Write and Edit, by End User, Through 2024
Table 6 : Chemical Building Blocks of DNA
Table 7 : DNA Translation and Transcription
Table 8 : Long-range DNA Structure
Table 9 : Genetic Variant Types
Table 10 : DNA Read, Write and Edit Technology Overview
Table 11 : Sequencing Technology Development, 1990-2020
Table 12 : Cost to Sequence a Single Human Genome, 2001-2019
Table 13 : Sequencing Technology Summary
Table 14 : Sanger Sequencing Summary
Table 15 : Sanger Sequencing Improvements
Table 16 : Advanced Sequencing Technologies
Table 17 : Roche Next-generation Sequencing Workflow
Table 18 : Illumina Next-generation Sequencing Workflow
Table 19 : Thermo Fisher Next-generation Sequencing Workflow
Table 20 : Comparison of Gene Synthesis Technologies
Table 21 : Importance of Microfluidics Technologies in Read and Write Applications
Table 22 : Gene Editing Therapeutic Interventions
Table 23 : Gene Editing Technology Approaches
Table 24 : Major Gene Editing Technologies
Table 25 : Comparison of CRISPR Enzyme Technologies
Table 26 : Delivery Vector Technical Hurdles
Table 27 : Comparison of Viral Vector Types
Table 28 : Non-Viral Delivery Methods
Table 29 : DNA Read, Write and Edit: R&D Programs
Table 30 : Population Sequencing Projects
Table 31 : Summary of Applications for DNA Read, Write and Edit Technologies
Table 32 : Role of DNA Read and Write Technologies in a Typical CRISPR Gene Editing Experiment
Table 33 : Sequencing Projects in GOLD Database, 2014-2018
Table 34 : Percentage Share of All Sequencing Projects in GOLD Database, by Sequencing Strategy, 2018
Table 35 : Main Sequencing Applications
Table 36 : Comparison of Genetic Analysis Platforms
Table 37 : Impact of Sequencing on Agricultural Product Classes
Table 38 : Key Applications in Forensics/Human Identity Sequencing
Table 39 : Key Applications in Microbial Sequencing
Table 40 : Genetic Testing Scope
Table 41 : Key Applications for Sequencing-based Diagnostics
Table 42 : Cancer Applications
Table 43 : Mendelian Disorders Applications
Table 44 : Reproductive Health Screening Applications
Table 45 : Ethical Issues Associated with Prenatal and Newborn Screening
Table 46 : Microbiology and Infectious Disease Applications
Table 47 : Complex Disorder Applications
Table 48 : Transplant Diagnostics Application
Table 49 : Oligonucleotide Applications
Table 50 : RNA Therapy Segments
Table 51 : Synthetic Gene Applications
Table 52 : Gene Editing Applications
Table 53 : Advanced Sequencing Industry Company Positioning
Table 54 : End-to-End Sequencing Approaches
Table 55 : Long-Read Sequencing Industry Players
Table 56 : Nucleic Acid Synthesis Key Competitor Strategies
Table 57 : RNA Therapy Segments
Table 58 : Producers of RNA Therapies
Table 59 : Gene Synthesis Workflow
Table 60 : Gene Synthesis Market Factors of Differentiation
Table 61 : Gene Editing Industry
Table 62 : Regulatory Situation of Gene-edited Crops, by Country/Region
Table 63 : DNA Read, Write and Edit Industry Acquisitions, January 2018-June 2019
Table 64 : DNA Read, Write and Edit Industry Strategic Alliances, January 2018-June 2019
Table 65 : Driving Forces for Growth in the DNA Read, Write and Edit Industry
Table 66 : Global DNA Read, Write and Edit Market, by Region, Through 2024
Table 67 : Global Market for DNA Read Sequencing, by Segment, Through 2024
Table 68 : Global Market for DNA Sequencing Instruments and Consumables, by Platform Generation, Through 2024
Table 69 : Global Market for DNA Sequencing Workflow Products, by Product Type, Through 2024
Table 70 : Global Market for DNA Sequencing Services, by End User, Through 2024
Table 71 : Global Market for Applied Sequencing Services, by Application, Through 2024
Table 72 : Driving Forces in the Growth of Synthetic Biology
Table 73 : Global Market for Clinical Diagnostics Sequencing, by Disease Category, Through 2024
Table 74 : Examples of Dilated Cardiomyopathy Test Providers
Table 75 : Microbial Sequencing Landscape
Table 76 : Multiple Sclerosis Diagnostic Technologies
Table 77 : Global Market for DNA Write Synthesis, by Product Type, Through 2024
Table 78 : Global Market for Oligonucleotides, by Application, Through 2024
Table 79 : Global Market for Synthetic Genes, by Type, Through 2024
Table 80 : Global Market for RNA Therapeutics, by Platform, Through 2024
Table 81 : GalNAc-conjugated RNA Therapy Pipeline
Table 82 : Global Market for RNA Therapeutics, by Disease Category, Through 2024
Table 83 : Global Market for Gene Editing, by End User, Through 2024
Table 84 : Global Market for Gene Editing, by Editing Platform, Through 2024
Table 85 : Global Market for Gene Editing Agriculture, by End Use Application, Through 2024
Table 86 : Advantages of Gene Editing for Crop Enhancement
Table 87 : Calyxt Market Potential of Gene-edited Crops
Table 88 : Commercialization Pathway for Gene-edited Crops
Table 89 : Global Market for Gene Editing Biotechnology, by Product Type, Through 2024
Table 90 : Global Market for Gene Editing Therapeutics, by Disease Category, Through 2024
Table 91 : Gene Editing Clinical Pipeline, 2019
Table 92 : CTC-related Patents, by Country/Region, 2008-2018
Table 93 : Exosome-related Patents, by Country/Region, 2008-2018
Table 94 : cfDNA-related Patents, by Country/Region, 2008-2018
Table 95 : Status of Liquid Biopsy and Sequencing-related Patent Disputes
Table 96 : CRISPR-Cas9 Patent Groups
Table 97 : CRISPR-Cas9 Patent Licensing Fields
Table 98 : Sangamos Collaborative Agreements Related to ZFN Technology
Table 99 : Sangamo Therapeutics Patent Positions
Table 100 : RNA Therapy Patents and Patent Applications, by Leading Companies
Table 101 : 23andMe: Data Generated by Platforms
Table 102 : Ginkgo Bioworks: Engineered-Organism Workflow
Table 103 : Homology Medicines: Gene Editing Vs. Gene Therapy Approach
Table 104 : PGT: Sensitivity to Detect Drug-resistant Mutations in Viruses
List Of Figures
Summary Figure : Global Market for DNA Read, Write and Edit, by Application, 2017-2024
Figure 1 : Central Dogma of Molecular Biology
Figure 2 : Schematic of Conventional DNA Synthesis Technologies
Figure 3 : Microarrays in DNA Synthesis
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