ADME/Tox Technologies

Global ADME/TOX market is mainly driven by the efforts of pharmaceutical and biotech companies for reducing time and cost of drug discovery. ADME/Tox profiling of a drug candidate plays a key role in reducing clinical trials cost and time of drug launch to the market. ADME/Tox assays eliminate compounds with lack of bioavailability, lower efficacy and toxicity in early stages, in order to save time and costs in expensive later stages of drug discovery.

This ADME/Tox Market research report gives an insight into products and services used in the ADME/Tox industry. Predictive technologies analyzed include In vivo, In vitro, and In silico. Related technologies such as High Throughput Screening (HTS), Laboratory Information Management System (LIMS), and cell based assays are also analyzed. Market projections and estimates are illustrated by region and by technology. The report serves as a guide to ADME/Tox industry, covering more than 280 companies that are engaged in ADME/Tox Market size/screening, products and services. Major Contract Research Organizations, Research Institutes and Universities serving the ADME/Tox industry are also covered in the corporate directory section of this report. Information related to recent product releases, product developments, partnerships, collaborations, and mergers and acquisitions is covered in the report. Compilation of Worldwide Patents related to ADME/Tox Technologies is also provided. A global perspective is presented along with regional analysis covering the regions of North America, Europe, Asia-Pacific, Latin America, the Middle East and Africa with 92 exclusive graphically represented exhibits. Key trends analyzed include ADME/TOX market growth, ADME Tox market potential, market shares, market size, and other market critical factors. This ADME/Tox market research provides historical, current, and market forecasts.
1. SCOPE AND METHODOLOGY
2. REPORT SYNOPSIS
2.1 ADME/Tox Technologies
Absorption
Distribution
Metabolism
Excretion
Toxicity
2.2 Significant Methods for ADME/Tox
Predictive Technologies
Related ADME/Tox Methods
2.3 ADME/Tox Technologies Global Market Analysis
Exhibit 1. ADME/Tox Technologies Global Market - Historic, Current, and Forecast (2010-2022) in US$ Billion
Exhibit 2. List of Major Global Companies in ADME/Tox Technologies Market
3. MARKET DYNAMICS
3.1 Market Overview
3.2. Global ADME/Tox Technologies Market Analysis
Exhibit 3. ADME/Tox Technologies Global Market - Historic, Current, and Forecast (2010-2022) for North America, Europe, Asia-Pacific, and Rest of World in US$ Million
Exhibit 4. ADME/Tox Technologies Global Market Shares (2012, 2018 & 2022) for North America, Europe, Asia-Pacific, and Rest of World
Exhibit 5. ADME/Tox Technologies Major Global Companies by Estimated Market Shares (%), 2015
3.3 North American ADME/Tox Technologies Market Analysis
Exhibit 6. ADME/Tox Technologies North American Market - Historic, Current, and Forecast (2010-2022) for United States and Canada in US$ Million
Exhibit 7. ADME/Tox Technologies North American Market Shares (2012, 2018 & 2022) for United States and Canada
3.3 (1) United States ADME/Tox Technologies Market
3.3 (II) Canadian ADME/Tox Technologies Market
Competitor Overview
Exhibit 8. List of Major ADME/Tox Companies in North America
3.4 European ADME/Tox Technologies Market Analysis
Exhibit 9. ADME/Tox Technologies European Market - Historic, Current, and Forecast (2010-2022) for Germany, United Kingdom, France, Sweden, Finland, Italy, Russia and Rest of Europe in US$ Million
Exhibit 10. ADME/Tox Technologies European Market Shares (2012, 2018 & 2022) for Germany, United Kingdom, France, Sweden, Finland, Italy, Russia and Rest of Europe
3.4 (1) German ADME/Tox Technologies Market
3.4 (II) United Kingdom ADME/Tox Technologies Market
3.4 (III) French ADME/Tox Technologies Market
3.4 (IV) Swedish ADME/Tox Technologies Market
3.4 (V) Finnish ADME/Tox Technologies Market
3.4 (VI) Italian ADME/Tox Technologies Market
3.4 (VII) Russian ADME/Tox Technologies Market
3.4 (VIII) Rest of European ADME/Tox Technologies Market
Analysis by Select Rest of Europe Countries
Exhibit 11. ADME/Tox Technologies Rest of Europe Market - Historic, Current, and Forecast (2010-2022) for Switzerland, Hungary, Spain, Austria, Belgium and Other European Countries in US$ Million
Exhibit 12. ADME/Tox Technologies Rest of Europe Market Shares (2012, 2018 & 2022) for Switzerland, Hungary, Spain, Austria, Belgium and Other European Countries
Competitor Overview
United Kingdom
Germany
Exhibit 13. List of Major ADME/Tox Companies in Europe
3.5 Asia-Pacific ADME/Tox Technologies Market Analysis
Exhibit 14. ADME/Tox Technologies Asia-Pacific Market - Historic, Current, and Forecast (2010-2022) for Japan, China, India, Australia, South Korea and Rest of Asia-Pacific in US$ Million
Exhibit 15. ADME/Tox Technologies Asia-Pacific Market Shares (2012, 2018 & 2022) for Japan, China, India, Australia, South Korea and Rest of Asia-Pacific
3.5 (I) Japanese ADME/Tox Technologies Market
3.5 (II) Chinese ADME/Tox Technologies Market
3.5 (III) Indian ADME/Tox Technologies Market
3.5 (IV) Australian ADME/Tox Technologies Market
3.5 (V) South Korean ADME/Tox Technologies Market
3.5 (VI) Rest of Asian ADME/Tox Technologies Market
Analysis by Select Rest of Asia-Pacific Countries
Exhibit 16. ADME/Tox Technologies Rest of Asia-Pacific Market - Historic, Current, and Forecast (2010-2022) for Singapore, Hong Kong and Other Asian Countries in US$ Million
Exhibit 17. ADME/Tox Technologies Rest of Asia-Pacific Market Shares (2012, 2018 & 2022) for Singapore, Hong Kong, and Other Asian Countries
Competitor Overview
China
Australia
Rest of Asia-Pacific
Exhibit 18. List of Major ADME/Tox Companies in Asia-Pacific
3.6 Rest of World ADME/Tox Technologies Market Analysis
Exhibit 19. ADME/Tox Technologies Rest of World Market - Historic, Current, and Forecast (2010-2022) for Brazil, South Africa, Israel and Other Countries in US$ Million
Exhibit 20. ADME/Tox Technologies Rest of World Market Shares (2012, 2018 & 2022) for Brazil, South Africa, Israel and Other Countries
3.6 (I) Brazilian ADME/Tox Technologies Market
3.6 (II) South African ADME/Tox Technologies Market
3.6 (III) Israeli ADME/Tox Technologies Market
3.6 (IV) ADME/Tox Technologies Market in Other Countries
Competitor Overview
Latin America
A few CROs operating in the Latin American Region
South African ADME/Tox Market
Middle East
3.7 Analysis by Technology
Exhibit 21. ADME/Tox Technologies Global Market - Historic, Current, and Forecast (2010-2022) by Technologies for In Vivo, In Vitro and In Silico in US$ Million
Exhibit 22. ADME/Tox Technologies Global Market Shares (2012, 2018 & 2022) by Technologies for In Vivo, In Vitro and In Silico
3.8 In Vivo ADME/Tox An Ever Growing Technology
3.8.1 Global In Vivo ADME/Tox Market Analysis
Exhibit 23. In Vivo ADME/Tox Technologies Global Market - Historic, Current, and Forecast (2010-2022) for North America, Europe, Asia-Pacific, and Rest of World in US$ Million
Exhibit 24. In Vivo ADME/Tox Technologies Global Market Shares (2012, 2018 & 2022) for North America, Europe, Asia-Pacific, and Rest of World
Exhibit 25. List of Global In Vivo ADME/Tox Companies
3.8.2 North American In Vivo ADME/Tox Market Analysis
Exhibit 26. In Vivo ADME/Tox Technologies North American Market - Historic, Current, and Forecast (2010-2022) for United States and Canada in US$ Million
Exhibit 27. In Vivo ADME/Tox Technologies North American Market Shares (2012, 2018 & 2022) for United States, and Canada
3.8.3 European In Vivo ADME/Tox Market Analysis
Exhibit 28. In Vivo ADME/Tox Technologies European Market - Historic, Current, and Forecast (2010-2022) for Germany, United Kingdom, France, Sweden, Finland, Italy, Russia and Rest of Europe in US$ Million
Exhibit 29. In Vivo ADME/Tox Technologies European Market Shares (2012, 2018 & 2022) for Germany, United Kingdom, France, Sweden, Finland, Italy, Russia and Rest of Europe
3.8.4 Asia-Pacific In Vivo ADME/Tox Market
Exhibit 30. In Vivo ADME/Tox Technologies Asia-Pacific Market - Historic, Current, and Forecast (2010-2022) for Japan, China, India, Australia, South Korea and Rest of Asia-Pacific in US$ Million
Exhibit 31. In Vivo ADME/Tox Technologies Asia-Pacific Market Shares (2012, 2018 & 2022) for Japan, China, India, Australia, South Korea and Rest of Asia-Pacific
3.8.5 Rest of World In Vivo ADME/Tox Market
Exhibit 32. In Vivo ADME/Tox Technologies Rest of World Market - Historic, Current, and Forecast (2010-2022) for Brazil, South Africa, Israel, and Other Countries in US$ Million
Exhibit 33. In Vivo ADME/Tox Technologies Rest of World Market Shares (2012, 2018 & 2022) for Brazil, South Africa, Israel, and Other Countries
3.9 In Vitro ADME/Tox An Emerging Technology
3.9.1 Global In Vitro ADME/Tox Market Analysis
Exhibit 34. In Vitro ADME/Tox Technologies Global Market - Historic, Current, and Forecast (2010-2022) for North America, Europe, Asia-Pacific, and Rest of World in US$ Million
Exhibit 35. In Vitro ADME/Tox Technologies Global Market Shares (2012, 2018 & 2022) for North America, Europe, Asia-Pacific, and Rest of World
Exhibit 36. List of Major Global In Vitro ADME/Tox Companies
3.9.2 North American In Vitro ADME/Tox Market Analysis
Exhibit 37. In Vitro ADME/Tox Technologies North American Market - Historic, Current, and Forecast (2010-2022) for United States and Canada in US$ Million
Exhibit 38. In Vitro ADME/Tox Technologies North American Market Shares (2012, 2018 & 2022) for United States, and Canada
3.9.3 European In Vitro ADME/Tox Market Analysis
Exhibit 39. In Vitro ADME/Tox Technologies European Market - Historic, Current, and Forecast (2010-2022) for Germany, United Kingdom, France, Sweden, Finland, Italy, Russia and Rest of Europe in US$ Million
Exhibit 40. In Vitro ADME/Tox Technologies European Market Shares (2012, 2018 & 2022) for Germany, United Kingdom, France, Sweden, Finland, Italy, Russia and Rest of Europe
3.9.4 Asia-Pacific In Vitro ADME/Tox Market Analysis
Exhibit 41. In Vitro ADME/Tox Technologies Asia-Pacific Market - Historic, Current, and Forecast (2010-2022) for Japan, China, India, Australia, South Korea and Rest of Asia-Pacific in US$ Million
Exhibit 42. In Vitro ADME/Tox Technologies Asia-Pacific Market Shares (2012, 2018 & 2022) for Japan, China, India, Australia, South Korea and Rest of Asia-Pacific
3.9.5 Rest of World In Vitro ADME/Tox Market
Exhibit 43. In Vitro ADME/Tox Technologies Rest of World Market - Historic, Current, and Forecast (2010-2022) for Brazil, South Africa, Israel and Other Countries in US$ Million
Exhibit 44. In Vitro ADME/Tox Technologies Rest of World Market Shares (2012, 2018 & 2022) for Brazil, Israel, South Africa, and Other Countries
3.10 In Silico ADME/Tox The Fastest Growing Technology
3.10.1 Global In Silico ADME/Tox Market Analysis
Exhibit 45. In Silico ADME/Tox Technologies Global Market - Historic, Current, and Forecast (2010-2022) for North America, Europe, Asia-Pacific, and Rest of World in US$ Million
Exhibit 46. In Silico ADME/Tox Technologies Global Market Shares (2012, 2018 & 2022) for North America, Europe, Asia-Pacific, and Rest of World
Exhibit 47. List of Major Global In Silico ADME/Tox Companies
3.10.2 North American In Silico ADME/Tox Market Analysis
Exhibit 48. In Silico ADME/Tox Technologies North American Market - Historic, Current, and Forecast (2010-2022) for United States and Canada in US$ Million
Exhibit 49. In Silico ADME/Tox Technologies North American Market Shares (2012, 2018 & 2022) for United States and Canada
3.10.3 European In Silico ADME/Tox Market Analysis
Exhibit 50. In Silico ADME/Tox Technologies European Market - Historic, Current, and Forecast (2010-2022) for Germany, United Kingdom, France, Sweden, Finland, Italy, Russia and Rest of Europe in US$ Million
Exhibit 51. In Silico ADME/Tox Technologies European Market Shares (2012, 2018 & 2022) for Germany, United Kingdom, France, Sweden, Finland, Italy, Russia and Rest of Europe
3.10.4 Asia-Pacific In Silico ADME/Tox Market Analysis
Exhibit 52. In Silico ADME/Tox Technologies Asia-Pacific Market - Historic, Current, and Forecast (2010-2022) for Japan, China, India, Australia, South Korea and Rest of Asia-Pacific in US$ Million
Exhibit 53. In Silico ADME/Tox Technologies Asia-Pacific Market Shares (2012, 2018 & 2022) for Japan, China, India, Australia, South Korea and Rest of Asia-Pacific
3.10.5 Rest of World In Silico ADME/Tox Market Analysis
Exhibit 54. In Silico ADME/Tox Technologies Rest of World Market - Historic, Current, and Forecast (2010-2022) for Brazil, South Africa, Israel, and Other Countries in US$ Million
Exhibit 55. In Silico ADME/Tox Technologies Rest of World Market Shares (2012, 2018 & 2022) for Brazil, South Africa, Israel, and Other Countries
3.11 Related Technologies
3.11.1 Laboratory Information Management Systems
Exhibit 56. Laboratory Information Management System (LIMS) Global Market - Historic, Current, and Forecast (2010-2022) in US$ Million
3.11.2 High Throughput Screening
3.11.2.1 Global HTS Market Analysis
Exhibit 57. High Throughput Screening (HTS) Global Market - Historic, Current, and Forecast (2010-2022) for North America, Europe, Asia-Pacific and Rest of World in US$ Million
Exhibit 58. High Throughput Screening (HTS) Global Market Shares (2012, 2018 & 2022) for North America, Europe, Asia-Pacific and Rest of World
3.11.2.2 Global HTS Products Market Analysis
Exhibit 59. HTS Products Global Market - Historic, Current, and Forecast (2010-2022) in US$ Million
3.11.2.3 Global Market Analysis for Re-Screening of Hits
Exhibit 60. Re-Screening of Hits Global Market - Historic, Current, and Forecast (2010-2022) in US$ Million
3.11.2.4 Global Market Analysis for HTS Services and Consumables
Exhibit 61. HTS Services and Consumables Global Market - Historic, Current, and Forecast (2010-2022) in US$ Billion
3.11.2.5 Global Market Analysis for HTS Services and Cell Based Consumables
Exhibit 62. HTS Services and Cell Based Consumables Global Market - Historic, Current, and Forecast (2010-2022) in US$ Billion
3.11.2.6 Global Spending on HTS for Lead Discovery
Exhibit 63. Spending on HTS for Lead Discovery Global Market - Historic, Current, and Forecast (2010-2022) for United States, Europe, and Rest of World in US$ Billion
3.11.3 Cell Based Assays
3.11.3.1 Global Market Analysis for Cell Based Assays
Exhibit 64. Cell-Based Assays Global Market - Historic, Current, and Forecast (2010-2022) for United States, Europe, Asia-Pacific, Canada and Rest of World in US$ Million
Exhibit 65. Cell-Based Assays Global Market Shares (2012, 2018 & 2022) for United States, Europe, Asia-Pacific, Canada and Rest of World
3.11.3.2 Global Pharmaceutical Cell Based Screening Market Analysis
Exhibit 66. Pharmaceutical Cell-Based Screening Global Market - Historic, Current, and Forecast (2010-2022) in US$ Billion
3.11.4 Global Drug Discovery Market Analysis
3.11.4.1 Global Drug Discovery Expenditure
Exhibit 67. Drug Discovery Expenditure Global Market - Historic, Current, and Forecast (2010-2022) in US$ Billion
3.11.4.2 US Market Analysis for Pharma Contract Research
Exhibit 68. Pharmaceutical Contract Research United States Market - Historic, Current, and Forecast (2010-2022) in US$ Billion
3.11.4.3 European Market Analysis for Drug Discovery
Exhibit 69. Drug Discovery European Market - Historic, Current, and Forecast (2010-2022) in US$ Billion
3.11.4.4 European Market Analysis for Drug Discovery Outsourcing
Exhibit 70. Drug Discovery Outsourcing European Global Market - Historic, Current, and Forecast (2010-2022) in US$ Billion
3.11.4.5 European Market Analysis for Nanotechnology Based Drug Discovery
Exhibit 71. Drug Discovery Based Nanotechnology European Market - Historic, Current, and Forecast (2010-2022) in US$ Million
3.11.4.6 Asia-Pacific Market Analysis for Drug Discovery
Drug Discovery Scenario in Asia-Pacific
Exhibit 72. Drug Discovery Asia-Pacific Market - Historic, Current, and Forecast (2010-2022) in US$ Billion
3.11.4.7 Asia-Pacific Market Analysis for Pharma CROs
Exhibit 73. Pharmaceutical Contract Research Organization Asia-Pacific Market - Historic, Current, and Forecast (2010-2022) in US$ Billion
3.11.5 Global Biotech Industry at a Glance
3.11.5.1 Major Research Areas in Biotechnology
Exhibit 74. Global Biotechnology Industry (2015): Percentage Breakdown of Major Research Areas
3.11.5.2 Canadian Market for Biotech R&D
Exhibit 75. Biotechnology R&D Expenditure Canadian Market - Historic, Current, and Forecast (2010-2022) in US$ Billion
3.11.5.3 European Biotech R&D
Exhibit 76. Biotechnology R&D Expenditure European Market - Historic, Current, and Forecast (2010-2022) in US$ Billion
3.12 ADME/Tox Technologies Market Outlook
Key Market Challenges
Other Side of the Coin
Key Market Drivers
4. COMPETITOR DYNAMICS
4.1 Company Profiles - Major Players in ADME/Tox Market
Admescope Ltd. (Finland)
Advanced Chemistry Development, Inc. (ACD/Labs) (Canada)
Agilent Technologies, Inc. (USA)
Agilux Laboratories, Inc. (USA)
Albany Molecular Research, Inc. (USA)
Bayer AG (Germany)
Bio-Rad Laboratories, Inc. (USA)
BioreclamationIVT (USA)
Cerep SA (France)
Certara LP (USA)
Charles River Laboratories International, Inc. (USA)
Chenomx, Inc. (Canada)
CompuDrug International, Inc. (USA)
Corning, Inc. (USA)
Covance, Inc. (USA)
Cyprotex plc (UK)
Dassault Systemes Biovia Corporation (USA)
Envigo (UK)
Eurofins Scientific SE (France)
GE Healthcare Life Sciences (UK)
GenPharmTox BioTech AG (Germany)
ID Business Solutions Ltd. (UK)
Kibron, Inc. (Finland)
Korea Institute of Toxicology (South Korea)
LHASA Ltd. (UK)
MilliporeSigma (USA)
Molecular Discovery Ltd. (UK)
MultiCASE, Inc. (USA)
Pharmaron, Inc. (USA)
Promega Corporation (USA)
QPS Holdings, LLC (USA)
Schrodinger LLC (USA)
Sciex (USA)
Sekisui Medical Co., Ltd. (Japan)
Sekisui XenoTech, LLC (USA)
Simulations Plus, Inc. (USA)
Sirius Analytical Instruments Ltd. (UK)
Sovicell GmbH (Germany)
Taconic Farms, Inc. (USA)
Tecan AG (Switzerland)
TetraQ (Australia)
Thermo Fisher Scientific, Inc. (USA)
Waters Corporation (USA)
WuXi AppTec Co., Ltd. (China)
Xceleron Ltd. (UK)
4.2 Major Activities in ADME/Tox Market
Evotec Plans to Acquire Cyprotex PLC
Certara Sets Up Phoenix PK/PD Centers of Excellence in Japan and China
Cyprotex Releases New DDI-Fusion Integrating Chemical Structure and In Vitro Data for the Prediction of DDI in Humans
Cyprotex Releases Supplementary Transporter Assays for Widening ADME Capabilities
Cyprotex Expands Proprietary Metabolite Identification Service
Certara Introduces Latest PK/PD Phoenix Software
Simulations Plus Unveils ADMET Predictor Version 8.0
More.
4.3 Major Product Introductions/Developments in ADME/Tox Market
Indigo Develops In-Vitro Toxicology Platform
Cyprotex Launches New Enhanced Version of chemPK Workflow Solution to Predict Human Pharmacokinetics Directly from Chemical Structure
Certara Launches SIVA Toolkit 2.0 to Advance Data Analysis for In-vitro Drug Development
Certara Launches Strategic Drug Development Consultancy Company in China
Certara Launches Simcyp Population-based Simulator Version 15
AMRI Launches Integrated Drug Discovery Center in the US
Agilux Laboratories Adds MDCK/MDCK-MDR1 to Its Collection of In-Vitro ADMET Assays
Certara Joins EU-ToxRisk A Program Driving Mechanism-based Toxicity Testing and Risk Assessment
XenoTech Adds In-Vitro Toxicology to Its Extensive Portfolio of Drug Development
Cyprotex Launches In-vitro Service Utilizing Spontaneously Beating Cardiac 3D Microtissues
More
5. PRODUCT/TECHNOLOGY RESEARCH
5.1 Introduction
ADME/Tox The Basics
Absorption
Distribution
Metabolism
Metabolism of Drugs
Phases of Detoxification
Phase I-Modification
Oxidation
Reduction
NADPH-cytochrome P 450 Reductase
Reduced (ferrous) Cytochrome P 450
Hydrolysis
Phase II Conjugation
Phase III More Modification and Excretion
Factors Affecting Metabolism of Drugs
Excretion
Toxicity
Factors Determined by ADME/Tox
ADME/Tox Properties are determined by -
The Increasing Need to Predict ADME/Tox Profiles
Preclinical ADME/Tox Evaluation Tools
Some of the Current Evaluation Tools for ADME/Tox in Use Include
Preclinical ADME/Tox Tools are generally validated for
5.2 ADME/Tox Essence of Pharmaceutical Industry
Drug Development - An Overview
Origin and Development of New Chemical Entity (NCE)
Process of Drug Development
Target Identification
Target Validation
Lead Identification
Technologies for Lead Generation
Common Technologies for Lead Generation Include -
Lead Optimization
Preclinical Trials
Technologies for Preclinical Development of Drug Candidates
Clinical Trials
Phase I
Phase II
Phase III
Exhibit 77. Drug Development Cost Historic, Current, and Forecast (2010-2022) in US$ Million
Major hurdles in drug development process are:
Stages of Drug Development
Exhibit 78. Critical Path for a Drug to Enter Clinical Trials
Improved Technology Infrastructure Increases Potential of Manufacturing Efficiency
Exhibit 79. Estimated Time Required for Development of Drugs by Primary Indication (In Years)
5.3 ADME/Tox in Drug Discovery Process
Factors Influencing Drug Approval Rates
Ideally, a successful DMPK drug -
Estimating Potential R&D Efficiency Gains from an Improved Technology Infrastructure
Reasons for the Decline in Success Rates
Exhibit 80. Reasons for Drug Failure in Clinical Trials Phase I III (Wirte the phases not the years)
5.4 ADME/Tox Methods
Predictive Technologies
Overlapping of Predictive ADME/Tox Technologies
Applications by Technology
Exhibit 81. Overlapping of Predictive ADME/Tox Technology Applications across Various Stages of Drug Discovery
Importance of In Vivo Tests
Exhibit 82. In Vivo ADME/Tox Methods
Modern In Vivo ADME/Tox Models
Zebrafish
Rodent Models
Drosophila
C.elegans
Conventional In Vivo ADME/Tox Models
Radiolabels
Cassette Dosing
Semi Simultaneous Dosing
Why do we Need Animals for Trials?
In Vitro ADMET
In Vitro Assays
Veterinary In Vitro Testing
Exhibit 83. Veterinary In Vitro Testing Technologies Global Market - Historic, Current, and Forecast (2010-2022) in US$ Million
In Vitro Applications for Drug Discovery and Development
Human and Animal Metabolism
Permeation Studies
Other ADME Services
Exhibit 84. In Vitro ADME/TOX Methods
Examples of Human in Vitro ADME/Tox Assays Include
Biological Assay Systems for the Evaluation of Cytochrome P450 Enzyme Isoforms
In Silico ADMET
In Silico Applications along Preclinical Stages
In Silico Predictive Models
Broad Segmentation of In Silico Technology
Analysis by Segment
Exhibit 85. In Silico ADME/Tox Global Value Market - Historic, Current, and Forecast (2010-2022) for Organ and Tissue Cells, Cellular Networks, and Whole Cells in US$ Million
Applications of In Silico Models in Drug Discovery Process
Potential Applications of In Silico Technology
Prediction of In Silico Profiles by Metabolic Behavior
In Silico Technologies Market Scenario
Prospects
Constraint
Related Technologies
Screening Technologies
The various types of screening technologies include
High Throughput Screening
Primary Screening
Secondary Screening
Biochemical Assays
Cell based Assays
High Content Screening
5.5 Toxicity
Toxicity An Overview
Exhibit 86. Percentage of Toxicities Leading to Drug Failures in Clinical Trials (Phase I-III)
Toxicology - Reason for Drug Failure
Preclinical Toxicology
Predictive Toxicology
Methods and Challenges Involving Predictive Toxicology in Drug Discovery & Development
Rule of Five
ADME/Tox Models (Statistical Significance / Mechanistic Interpretation)
Challenges of ADME/Tox Prediction
Determining Factors for Effective Predictive Toxicology in Preclinical Stage
Remedial Measures
Types of Toxicities
Exhibit 87. Common Types of Toxicity Targeted for ADME/TOX Predictive Techniques
Hepatotoxicity or Drug Induced Liver Injury (DILI)
Metabolism of Drugs
Metabolism of Drug in Liver
Factors Resulting in Liver Damage
Drug Response
Future Prospects
Cardiotoxicity
Diagnosis
Cardiovascular Toxicity and QT Prolongation
Nephrotoxicity
Diagnosis
Neurotoxicity
Pulmonary Toxicity
Diagnosis
Pulmonary Toxicity Due to Medicinal Drugs
Pulmonary Toxicity Due to Radiation (Radiotherapy)
Pulmonary Toxicity Due to Chemical Compounds
Pulmonary Toxicity Due to Particulate Matter (cars, industry, etc)
Myotoxicity or Muscle Related Diseases
Dermatoxicity or Skin Related Allergies
Phototoxicity
Oculotoxicity
Reproductive Toxicity
Genotoxicity
Ames Testing to Confirm Genotoxicity
Genotoxicity and its Serious Impact on Regulatory Agencies
Hematotoxicity
Carcinogenicity
Cytotoxicity
Torsades de pointes
Exhibit 88. Common Approved In Vitro and In Vivo Procedures
Types of Predictive Toxicology
Computational Toxicology
QSAR
In Vitro Toxicology
Exhibit 89. Non-animal Methods being Considered for Validation
In Vitro Toxicology Liver Cell Models
Tissue Culture Systems Used in In Vitro Toxicology
In Vitro Toxicology Applications
Genomics in Toxicity Testing
Examining Neurotoxicity
Alternatives for Animals in Toxicity Testing
Exhibit 90. Common Animals Used for ADME and Toxicity Testing
Exhibit 91. In vivo Animal Models for Toxicity Tests and their Importance
5.6 ADME/TOX and Drug Discovery Technologies
Pharmacogenomics
Pharmacokinetics
LADMET-R and Pharmacokinetics
ADME Associated Proteins
A Category
D Category
M Category
E Category
Exhibit 92. Classification of Protein Targets by Category
Proteomics
Bioinformatics
Challenges Facing the ADME/Tox Industry
5.7 ADME/TOX Technologies Research Briefs
Computing toxic chemicals
Faster smarter and cheaper drug discovery
Novel drug screening process gives long sought anti-HIV compounds-Potential drugs acts on target that are not likely to mutate
Validation of the Preclinical efficacy of the TB drug target
Genomics of ADME
The edge of the drug development
Pharmacogenetics Testing Provides Way to Decrease Deaths Caused by Drug Toxicity
A computer/test tube combination provides the best drug developments results ever
Comprehensive study indicating better time frame of a drug remaining in its target (residence time) leads to enhanced therapeutic and diagnostic agents
Drug Metabolism Interaction of Enzymes and its Significance to Toxicity and Effectiveness
Zebrafish the latest entrant in the drug Development process
Novel methods in the development of Functional Hepatocytes explored by Scientists
The protocol to eliminate costly missteps in the process of drug development
Avoiding Expensive Missteps in Developing Drugs
MetaChip for rapid and effective toxicity screening protocol for potential drugs
6. CORPORATE DIRECTORY
7. PATENTS

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