Liposarcoma - Pipeline Insight, 2021

DelveInsights, Liposarcoma - Pipeline Insight, 2021, report provides comprehensive insights about 15+ companies and 15+ pipeline drugs in Liposarcoma pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered
Global coverage

Liposarcoma Understanding
Liposarcoma: Overview
Liposarcomas are rare type of malignant tumors of fatty tissue. They are the second most common type of soft-tissue sarcoma. Liposarcoma can occur in fat cells in any part of the body, but most cases occur in the muscles of the limbs or in the abdomen. Liposarcomas are typically found in adults, typically between the ages of 40 and 60, and are rare in children. Liposarcoma occurs more often in men than women. Liposarcoma risk factors may include radiation, family cancer syndromes, a damaged lymph system, and/or exposure to certain chemicals. Liposarcoma stages describe the extent of tumor spread with stage IV representing the most extensive cancer with metastatic spread. Liposarcoma can be diagnosed by imaging the body by X-ray, computed tomography (CT) or magnetic resonance imaging (MRI). Therapy to treat liposarcoma largely depends on the type, size and location of the tumor. Treatments for liposarcoma include: Surgery, Radiation therapy, and Chemotherapy. New therapies are under clinical trials assessment as a potential treatment for liposarcomas.

"Liposarcoma - Pipeline Insight, 2021" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Liposarcoma pipeline landscape is provided which includes the disease overview and Liposarcoma treatment guidelines. The assessment part of the report embraces, in depth Liposarcoma commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Liposarcoma collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Report Highlights
The companies and academics are working to assess challenges and seek opportunities that could influence Liposarcoma R&D. The therapies under development are focused on novel approaches to treat/improve Liposarcoma.

Liposarcoma Emerging Drugs Chapters
This segment of the Liposarcoma report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Liposarcoma Emerging Drugs

RAIN-32: Rain Therapeutics
RAIN-32 (milademetan) is a small molecule based oral inhibitor of mouse double minute 2 (MDM2). MDM2 is a critical regulator of tumor protein 53 (p53), which is known as the guardian of the genome. RAIN-32 is in Phase III clinical studies for the treatment of Liposarcoma.

Selinexor: Karyopharm Therapeutics
Selinexor is a first-in-class selective inhibitor of nuclear transport (SINE) compound. The molecule functions by binding with, and inhibiting, the nuclear export protein, XPO1, leading to the accumulation of tumor suppressor proteins in the cell nucleus. Selinexor, with the brand name XPOVIO, has been approved by the USFDA for relapsed or refractory multiple myeloma, relapsed or refractory diffuse large B-cell lymphoma (DLBCL), and in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma who have received at least one prior therapy. The drug is in Phase III clinical studies for the treatment of Liposarcoma.
Further product details are provided in the report..

Liposarcoma: Therapeutic Assessment
This segment of the report provides insights about the different Liposarcoma drugs segregated based on following parameters that define the scope of the report, such as:
Major Players in Liposarcoma
There are approx. 15+ key companies which are developing the therapies for Liposarcoma. The companies which have their Liposarcoma drug candidates in the most advanced stage, i.e. Phase III include, Rain Therapeutics.

Phases
DelveInsights report covers around 15+ products under different phases of clinical development like
Late stage products (Phase III)
Mid-stage products (Phase II)
Early-stage product (Phase I) along with the details of
Pre-clinical and Discovery stage candidates
Discontinued & Inactive candidates

Route of Administration
Liposarcoma pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
Oral
Parenteral
Intravitreal
Subretinal
Topical

Molecule Type
Products have been categorized under various Molecule types such as
Monoclonal Antibody
Peptides
Polymer
Small molecule
Gene therapy

Product Type
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Liposarcoma: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses Liposarcoma therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Liposarcoma drugs.

Liposarcoma Report Insights
Liposarcoma Pipeline Analysis
Therapeutic Assessment
Unmet Needs
Impact of Drugs

Liposarcoma Report Assessment
Pipeline Product Profiles
Therapeutic Assessment
Pipeline Assessment
Inactive drugs assessment
Unmet Needs

Key Questions
Current Treatment Scenario and Emerging Therapies:
How many companies are developing Liposarcoma drugs?
How many Liposarcoma drugs are developed by each company?
How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Liposarcoma?
What are the key collaborations (IndustryIndustry, IndustryAcademia), Mergers and acquisitions, licensing activities related to the Liposarcoma therapeutics?
What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
What are the clinical studies going on for Liposarcoma and their status?
What are the key designations that have been granted to the emerging drugs?

Key Players
Karyopharm Therapeutics
Rain Therapeutics
Pfizer
Sanofi
Incyte Corporation
Macrogenics
Adaptimmune
Merck KGaA
GlaxoSmithKline
Novartis Oncology
Immune Design
Syndivia
TerSera Therapeutics

Key Products
RAIN-32
PF-07220060
Selinexor
Cabazitaxel
Retifanlimab
Afamitresgene autoleucel
Avelumab
Letetresgene autoleucel
Ribociclib
LV 305
CMB 305
SDV-1101
Telotristat etiprate

Introduction
Executive Summary
Liposarcoma: Overview
Causes
Mechanism of Action
Signs and Symptoms
Diagnosis
Disease Management
Pipeline Therapeutics
Comparative Analysis
Therapeutic Assessment
Assessment by Product Type
Assessment by Stage and Product Type
Assessment by Route of Administration
Assessment by Stage and Route of Administration
Assessment by Molecule Type
Assessment by Stage and Molecule Type
Liposarcoma DelveInsights Analytical Perspective
Late Stage Products (Phase III)
Comparative Analysis
RAIN-32: Rain Therapeutics
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report..
Mid Stage Products (Phase II)
Comparative Analysis
Cabazitaxel: Sanofi
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report..
Early Stage Products (Phase I/II)
Comparative Analysis
Ribociclib: Novartis Oncology
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report..
Preclinical and Discovery Stage Products
Comparative Analysis
SDV-1101: Syndivia
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report..
Inactive Products
Comparative Analysis
Liposarcoma Key Companies
Liposarcoma Key Products
Liposarcoma- Unmet Needs
Liposarcoma- Market Drivers and Barriers
Liposarcoma- Future Perspectives and Conclusion
Liposarcoma Analyst Views
Appendix

List Of Tables

Table 1 Total Products for Liposarcoma
Table 2 Late Stage Products
Table 3 Mid Stage Products
Table 4 Early Stage Products
Table 5 Pre-clinical & Discovery Stage Products
Table 6 Assessment by Product Type
Table 7 Assessment by Stage and Product Type
Table 8 Assessment by Route of Administration
Table 9 Assessment by Stage and Route of Administration
Table 10 Assessment by Molecule Type
Table 11 Assessment by Stage and Molecule Type
Table 12 Inactive Products

List Of Figures

Figure 1 Total Products for Liposarcoma
Figure 2 Late Stage Products
Figure 3 Mid Stage Products
Figure 4 Early Stage Products
Figure 5 Preclinical and Discovery Stage Products
Figure 6 Assessment by Product Type
Figure 7 Assessment by Stage and Product Type
Figure 8 Assessment by Route of Administration
Figure 9 Assessment by Stage and Route of Administration
Figure 10 Assessment by Molecule Type
Figure 11 Assessment by Stage and Molecule Type
Figure 12 Inactive Products

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