Postoperative nausea and vomiting (PONV) - Market Insights, Epidemiology, and Market Forecast-2028

Postoperative nausea and vomiting (PONV) - Market Insights, Epidemiology, and Market Forecast-2028 report deliver an in-depth understanding of the disease, historical and forecasted epidemiology as well as the market trends of PONV in the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan.
Postoperative nausea and vomiting (PONV) is an enormous problem for patients recovering after surgery. About one-third of people experience vomiting, and half of them experience nausea. Nausea, retching, or vomiting usually occurs during the first 2448 h after surgery in inpatients. PONV is a common side effect following sedation and general anesthesia.
If these symptoms occur from 24 h following the discharge up to 72 h, it is called postdischarge nausea and vomiting (PDNV). In preoperative surveys, PONV is rated as the most likely to avoid anesthesia outcomes by the patients.

Geography Covered
The United States
EU5 (Germany, France, Italy, Spain, and the United Kingdom)
Japan

Study Period: 20172028
PONVDisease Understanding
Postoperative nausea and vomiting (PONV) can be one of the most distressing parts of the surgical journey. It affects approximately 2030% of patients within the first 2448 h postsurgery. Unresolved PONV may result in prolonged postanesthesia care unit (PACU) stay and unanticipated hospital admission that results in a significant increase in overall health care costs. The goal of PONV prophylaxis is, therefore, to decrease the cases of PONV and thus patient-related distress and reduce health care costs.

PONV Epidemiology
The disease epidemiology covered in the report provides historical as well as forecasted epidemiology (Total Inpatient Surgical Cases in the 7MM, Total Number of Patients taking antiemetic treatment (prophylactic) or not taking anti-emetics in the 7MM, Total Number of Patient showing Nausea and Vomiting in the 7MM and Total Number of Post-operative Nausea and Vomiting patients in the 7MM, scenario of PONV in the 7MM covering United States, EU5 countries (Germany, France, Italy, Spain, and United Kingdom) and Japan from 20172028.
According to , the total inpatients surgical cases in the 7 major markets was 52,032,174 in 2017. These cases are increases with a significant CAGR during study period (2017-2028). The total PONV cases in the 7 major markets was 16,980,822 in 2017.

PONV Drug Chapters
The treatment strategy includes single and combination of the antiemetic, which works on different receptor classes that result in additive effects. The major drug classes used for prophylaxis and treatment of PONV include histamine receptor antagonists, muscarinic receptor antagonists, dopamine receptor antagonists, serotonin type 3 (5-HT3) receptor antagonists, and tachykinin 1 (NK1) receptor, antagonists.

The three therapies which are approved in the US for the management of PONV after 2000 are Aloxi, Zuplenz, and Emend. In September 2019, the PONV indication was removed from the Emend capsule as per the US prescription information; however, it remains in the labeling for generic aprepitant capsules. Other PONV drugs, which are discontinued in the US are Kytril, Phenergan, and Compazine. The generic versions of most of the therapies approved before 2000 are currently utilized for the management of PONV.
Aloxi is an intravenous palonosetron hydrochloride injection developed by Eisai Corporation of North America, its US subsidiary MGI Pharma, and Helsinn Healthcare. In February 2008, the US FDA approved Aloxi IV injection for the prevention of PONV for up to 24 h following surgery. In phase III clinical study the most frequently observed side effects with Aloxi were electrocardiogram (ECG) QT prolongation (five percent), bradycardia (four percent), headache (three percent), and constipation (two percent) (Eisai Corporation, 2008).
Zuplenz is an oral soluble film containing ondansetron in 4 mg and 8 mg strength. In July 2011, it was approved in the US for the prevention of PONV. The patents of Aloxi and Zuplenz will expire in 2024 and 2030, respectively.

Post-Operative Nausea and Vomiting (PONV) Market Outlook
The market size of PONV in the seven major markets (7MM) was USD 1,890.53 million in 2017. In addition, the Prophylactic and Rescue treatment market size of PONV in the seven major markets (7MM) was USD 1,272.81 million and USD 617.72 million in 2017.

Post-Operative Nausea and Vomiting (PONV) Drugs Uptake
There are only a few companies that are working for the management of PONV, and that includes Acacia Pharma (Barhemsys), Cara Therapeutics (CR845), Braeburn Pharmaceuticals, and Camurus.
Barhemsys (formerly known as APD421 and Baremsis) is an intravenous formulation of amisulpride, a selective small-molecule dopamine antagonist, which has completed phase III clinical development for the prophylaxis and treatment of PONV, alone and in combination with other antiemetic.
CR845 (also known as difelikefalin) which is under development by Cara is an analgesic opioid peptide acting as a peripherally specific, highly selective agonist of the kappa opioid receptor. It is currently investigated in phase II/III clinical study for the management of PONV.

PONV Report Insights
Patient Population by total Inpatient Surgical cases
Total PONV cases
Therapeutic Approaches
Pipeline Analysis
Market Size and Trends
Market Opportunities
Impact of upcoming Therapies

PONV Report Key Strengths
10 Year Forecast
7MM Coverage
Epidemiology Segmentation
Drugs Uptake
Highly Analyzed Market
Key Cross Competition

PONV Report Assessment
Current Treatment Practices
Unmet Needs
Detailed Pipeline Product Profiles
Market Attractiveness
Market Drivers and Barriers

Key Benefits
This report will help to develop Business Strategies by understanding the trends shaping and driving the PONV market
Organize sales and marketing efforts by identifying the best opportunities for PONV market
To understand the future market competition in the PONV market.

List Of Tables

Table 1 Candidate genes that affect nausea and vomiting
Table 2 Total Inpatient Surgeries in the 7MM (20172028)
Table 3 Total Postoperative Nausea and Vomiting (PONV) Cases in the 7MM (2017-2028)
Table 4 Total Inpatient Surgery Cases in the United States (2017-2028)
Table 5 Total Number of Patients taking antiemetic treatment (prophylactic) or not taking anti-emetics in the United States (2017-2028)
Table 6 Total Number of Post-Operative Nausea and Vomiting patients in the United States (2017-2028)
Table 7 Total Inpatient Surgery Cases in Germany (2017-2028)
Table 8 Total Number of Patients taking antiemetic treatment (prophylactic) or not taking anti-emetics in Germany (2017-2028)
Table 9 Total Number of Post-Operative Nausea and Vomiting patients in Germany (2017-2028)
Table 10 Total Inpatient Surgery Cases in France (2017-2028)
Table 11 Total Number of Patients taking antiemetic treatment (prophylactic) or not taking anti-emetics in France (2017-2028)
Table 12 Total Number of Post-Operative Nausea and Vomiting patients in France (2017-2028)
Table 13 Total Inpatient Surgery Cases in Italy (2017-2028)
Table 14 Total Number of Patients taking antiemetic treatment (prophylactic) or not taking anti-emetics in Italy (2017-2028)
Table 15 Total Number of Post-Operative Nausea and Vomiting patients in Italy (2017-2028)
Table 16 Total Inpatient Surgery Cases in Spain (2017-2028)
Table 17 Total Number of Patients taking antiemetic treatment (prophylactic) or not taking anti-emetics in Spain (2017-2028)
Table 18 Total Number of Post-Operative Nausea and Vomiting patients in Spain (2017-2028)
Table 19 Total Inpatient Surgery Cases in the UK (2017-2028)
Table 20 Total Number of Patients taking antiemetic treatment (prophylactic) or not taking anti-emetics in the UK (2017-2028)
Table 21 Total Number of Post-Operative Nausea and Vomiting patients in the UK (2017-2028)
Table 22 Total Inpatient Surgery Cases in Japan (2017-2028)
Table 23 Total Number of Patients taking antiemetic treatment (prophylactic) or not taking anti-emetics in Japan (2017-2028)
Table 24 Total Number of Post-Operative Nausea and Vomiting patients in Japan (2017-2028)
Table 25 Advantages and side effects of different classes of antiemetic
Table 26 Recommended dosages of antiemetic drugs for prophylaxis in adult patients
Table 27 Pharmacologic combination therapy for adults and children
Table 28 Antiemetic doses for prophylaxis of POV in children
Table 29 Antiemetic Doses and Timing for Prevention of Postoperative Nausea and Vomiting in Adult
Table 30 Recommendations by the French Society of Anesthesia and Resuscitation
Table 31 Barhemsys patents
Table 32 Barhemsys, Clinical Trial Description, 2019
Table 33 CR845, Clinical Trial Description, 2019
Table 34 CAM2058, Clinical Trial Description, 2019
Table 35 Market size of PONV by Region in USD Million (20172028)
Table 36 7MM Size of PONV Prophylactic Market by Current and Emerging Therapies in USD Million (2017-2028)
Table 37 7MM Size of PONV Rescue Treatment by Current Treatment and Emerging Therapies in USD Million (2017-2028)
Table 38 7MM Size of PONV by Therapies in USD Million (2017-2028)
Table 39 United States Market Size of PONV in USD Million (2017-2028)
Table 40 The US Market Size of PONV Prophylactic Market by Current and Emerging Therapies in USD Million (2017-2028)
Table 41 The US Market Size of PONV Rescue Treatment by Current Treatment and Emerging Therapies in USD Million (2017-2028)
Table 42 The US Market Size of PONV by Therapies in USD Million (2017-2028)
Table 43 Germany Market Size of PONV in USD Million (2017-2028)
Table 44 Germany Market Size of PONV Prophylactic Market by Current and Emerging Therapies in USD Million (2017-2028)
Table 45 Germany Market Size of PONV Rescue Treatment by Current Treatment and Emerging Therapies in USD Million (2017-2028)
Table 46 Germany Market Size of PONV by Therapies in USD Million (2017-2028)
Table 47 France Market Size of PONV in USD Million (2017-2028)
Table 48 France Market Size of PONV Prophylactic Market by Current and Emerging Therapies in USD Million (2017-2028)
Table 49 France Market Size of PONV Rescue Treatment by Current Treatment and Emerging Therapies in USD Million (2017-2028)
Table 50 France Market Size of PONV by Therapies in USD Million (2017-2028)
Table 51 Italy Market Size of PONV in USD Million (2017-2028)
Table 52 Italy Market Size of PONV Prophylactic Market by Current and Emerging Therapies in USD Million (2017-2028)
Table 53 Italy Market Size of PONV Rescue Treatment by Current Treatment and Emerging Therapies in USD Million (2017-2028)
Table 54 Italy Market Size of PONV by Therapies in USD Million (2017-2028)
Table 55 Spain Market Size of PONV in USD Million (2017-2028)
Table 56 Spain Market Size of PONV Prophylactic Market by Current and Emerging Therapies in USD Million (2017-2028)
Table 57 Spain Market Size of PONV Rescue Treatment by Current Treatment and Emerging Therapies in USD Million (2017-2028)
Table 58 Spain Market Size of PONV by Therapies in USD Million (2017-2028)
Table 59 United Kingdom Market Size of PONV in USD Million (2017-2028)
Table 60 UK Market Size of PONV Prophylactic Market by Current and Emerging Therapies in USD Million (2017-2028)
Table 61 UK Market Size of PONV Rescue Treatment by Current Treatment and Emerging Therapies in USD Million (2017-2028)
Table 62 UK Market Size of PONV by Therapies in USD Million (2017-2028)
Table 63 Japan Market Size of PONV in USD Million (2017-2028)
Table 64 Japan Market Size of PONV Prophylactic Market by Current and Emerging Therapies in USD Million (2017-2028)
Table 65 Japan Market Size of PONV Rescue Treatment by Current Treatment and Emerging Therapies in USD Million (2017-2028)
Table 66 Japan Market Size of PONV by Therapies in USD Million (2017-2028)

List Of Figures

Figure 1 Causes of vomiting
Figure 2 Risk factors associated with PONV
Figure 3 Neural pathways and pharmacology of PONV
Figure 4 Total Inpatient Surgeries in the 7MM (2017-2028)
Figure 5 Total Postoperative Nausea and Vomiting (PONV) Cases in the 7MM (2017-2028)
Figure 6 Total Inpatient Surgery Cases in the United States (2017-2028)
Figure 7 Total Number of Patients taking antiemetic treatment (prophylactic) or not taking anti-emetics in the United States (2017-2028)
Figure 8 Total Number of Post-Operative Nausea and Vomiting patients in the United States (2017-2028)
Figure 9 Total Inpatient Surgery Cases in Germany (2017-2028)
Figure 10 Total Number of Patients taking antiemetic treatment (prophylactic) or not taking anti-emetics in Germany (2017-2028)
Figure 11 Total Number of Post-Operative Nausea and Vomiting patients in Germany (2017-2028)
Figure 12 Total Inpatient Surgery Cases in France (2017-2028)
Figure 13 Total Number of Patients taking antiemetic treatment (prophylactic) or not taking anti-emetics in France (2017-2028)
Figure 14 Total Number of Post-Operative Nausea and Vomiting patients in France (2017-2028)
Figure 15 Total Inpatient Surgery Cases in Italy (2017-2028)
Figure 16 Total Number of Patients taking antiemetic treatment (prophylactic) or not taking anti-emetics in Italy (2017-2028)
Figure 17 Total Number of Post-Operative Nausea and Vomiting patients in Italy (2017-2028)
Figure 18 Total Inpatient Surgery Cases in Spain (2017-2028)
Figure 19 Total Number of Patients taking antiemetic treatment (prophylactic) or not taking anti-emetics in Spain (2017-2028)
Figure 20 Total Number of Post-Operative Nausea and Vomiting patients in Spain (2017-2028)
Figure 21 Total Inpatient Surgery Cases in the UK (2017-2028)
Figure 22 Total Number of Patients taking antiemetic treatment (prophylactic) or not taking anti-emetics in the UK (2017-2028)
Figure 23 Total Number of Post-Operative Nausea and Vomiting patients in the UK (2017-2028)
Figure 24 Total Inpatient Surgery Cases in Japan (2017-2028)
Figure 25 Total Number of Patients taking antiemetic treatment (prophylactic) or not taking anti-emetics in Japan (2017-2028)
Figure 26 Total Number of Post-Operative Nausea and Vomiting patients in Japan (2017-2028)
Figure 27 Algorithm for the management of PONV
Figure 28 Algorithm for PONV prophylaxis
Figure 29 Algorithm for PONV prophylaxis
Figure 30 Unmet needs of PONV
Figure 31 Market size of PONV by Region in USD Million (20172028)
Figure 32 7MM Market Size of PONV Prophylactic Market by Current and Emerging Therapies in USD Million (2017-2028)
Figure 33 7MM Size of PONV Rescue Treatment by Current Treatment and Emerging Therapies in USD Million (2017-2028)
Figure 34 Market Size of PONV by Therapies in the 7MM, in USD Million (20172028)
Figure 35 United States Market Size of PONV in USD Million (2017-2028)
Figure 36 The US Market Size of PONV Prophylactic Market by Current and Emerging Therapies in USD Million (2017-2028)
Figure 37 The US Market Size of PONV Rescue Treatment by Current Treatment and Emerging Therapies in USD Million (2017-2028)
Figure 38 The US Market Size of PONV by Therapies in USD Million (2017-2028)
Figure 39 Germany Market Size of PONV in USD Million (2017-2028)
Figure 40 Germany Market Size of PONV Prophylactic Market by Current and Emerging Therapies in USD Million (2017-2028)
Figure 41 Germany Market Size of PONV Rescue Treatment by Current Treatment and Emerging Therapies in USD Million (2017-2028)
Figure 42 Germany Market Size of PONV by Therapies in USD Million (2017-2028)
Figure 43 France Market Size of PONV in USD Million (2017-2028)
Figure 44 France Market Size of PONV Prophylactic Market by Current and Emerging Therapies in USD Million (2017-2028)
Figure 45 France Market Size of PONV Rescue Treatment by Current Treatment and Emerging Therapies in USD Million (2017-2028)
Figure 46 France Market Size of PONV by Therapies in USD Million (2017-2028)
Figure 47 Italy Market Size of PONV in USD Million (2017-2028)
Figure 48 Italy Market Size of PONV Prophylactic Market by Current and Emerging Therapies in USD Million (2017-2028)
Figure 49 Italy Market Size of PONV Rescue Treatment by Current Treatment and Emerging Therapies in USD Million (2017-2028)
Figure 50 Italy Market Size of PONV by Therapies in USD Million (2017-2028)
Figure 51 Spain Market Size of PONV in USD Million (2017-2028)
Figure 52 Spain Market Size of PONV Prophylactic Market by Current and Emerging Therapies in USD Million (2017-2028)
Figure 53 Spain Market Size of PONV Rescue Treatment by Current Treatment and Emerging Therapies in USD Million (2017-2028)
Figure 54 Spain Market Size of PONV by Therapies in USD Million (2017-2028)
Figure 55 United Kingdom Market Size of PONV in USD Million (2017-2028)
Figure 56 UK Market Size of PONV Prophylactic Market by Current and Emerging Therapies in USD Million (2017-2028)
Figure 57 UK Market Size of PONV Rescue Treatment by Current Treatment and Emerging Therapies in USD Million (2017-2028)
Figure 58 UK Market Size of PONV by Therapies in USD Million (2017-2028)
Figure 59 Japan Market Size of PONV in USD Million (2017-2028)
Figure 60 Japan Market Size of PONV Prophylactic Market by Current and Emerging Therapies in USD Million (2017-2028)
Figure 61 Japan Market Size of PONV Rescue Treatment by Current Treatment and Emerging Therapies in USD Million (2017-2028)
Figure 62 Japan Market Size of PONV by Therapies in USD Million (2017-2028)
Figure 63 Market Drivers
Figure 64 Market Barriers
Figure 65 SWOT analysis

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