Tumor Infiltrating Lymphocytes: A New Frontier in Cancer Immunotherapy

Report Includes:

- An overview of Tumor Infiltrating Lymphocytes (TILs) for the treatment of metastatic cancer
- Discussion of the development of TIL as a treatment option for melanoma and the possibilities to expand this therapy to other types of cancer
- Exploration of adoptive T-cell therapy (ATCT) using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma, and the curative potential of ATCT in a variety of other solid tumors
- Comparison between two main technologies of tumor immunotherapy, chimeric antibody receptor engineered T Cell (CAR-T) and genetically modified T cell receptors (TCR)
- Information on the role of TILs as a strong prognostic biomarker for triple-negative breast cancer (TNBC) and their potential ramifications


Chapter 1 The Emergence of Cell Therapy Using TILs
Introduction
Analysts Credentials
Related Reports
Chapter 2 Development of TIL Therapies in Metastic Melanoma
TIL Generation Explained
Importance of Lymphodepletion
Role of Interleukin-2
Feasibility of TIL as a Mainstream Treatment Option
Chapter 3 Development of TIL Therapies in Other Tumour Types
Cervical Cancer
Ovarian Cancer
Kidney Cancer
Gastrointestinal Cancer
Head and Neck Cancers
Chapter 4 Clinical Development of TIL Therapies
Lifileucel (LN-144), Iovance Biotherapeutics
LN-145, Iovance Biotherapeutics
TILT-123, TILT Biotherapeutics
Optera Therapeutics Corp.
Other Centers Conducting TIL Research
Future Perspectives for TIL
Chapter 5 References


List Of Tables


Table 1 : TILs and Tumor Specific Antigens
Table 2 : Adoptive T-Cell Therapy (ATC) Cellular Therapies
Table 3 : Clinical Trials Studying TIL Therapies


List Of Figures


Figure 1 : Generation of Tumor Infiltrating Lymphocytes
Figure 2 : IL-2 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types
Figure 3 : TILT Biotherapeutics Development Pipeline


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