Synthetic Biology: Global Markets

Report Scope:

The study scope includes core synthetic biology products (e.g., oligonucleotides, synthetic genes, BioBrick parts, delivery plasmids, chassis organisms, synthetic cells, cell-based and cell-free production systems), enabling technologies (e.g., DNA sequencing, DNA synthesis, gene editing, bioinformatics, specialty media) and enabled technologies (e.g., healthcare, industrial chemicals, consumer products, food and beverage, agriculture) that are already commercialized or are forecast to be commercialized through 2024.

Key synthetic biology technologies and products are analyzed to determine present and future market status, as well as forecasted growth from 2019 to 2024. In-depth discussion of strategic alliances, industry structures, competitive dynamics, patents and market driving forces is also provided.

examines the synthetic biology industry by market segment, including DNA sequencing, DNA synthesis, gene editing, synthetic biology foundries and software; as well as the agriculture; consumer products, cosmetics and skin care, food and beverage, healthcare and industrial chemicals enable product sectors.

The role of key strategic alliances and acquisitions from January 2018 to September 2019 is discussed. Emerging markets, including synthetic genes, synthetic-biology-enabled drugs and vaccines, genome-edited crops and chassis organisms; as well as metabolically engineered factories for producing synthetic fuels and specialty chemicals, are analyzed, and more than 215 companies in these fields are highlighted.

Report Includes:

- 29 data tables and 100 additional tables
- An overview of the global markets for synthetic biology
- Analyses of global market trends, with data from 2018, 2019, and projections of compound annual growth rates (CAGRs) through 2024
- Description of core synthetic biology products i.e. synthetic genes, DNA parts, chassis organisms, and synthetic cells
- Information on enabling technologies such as DNA sequencing, oligonucleotides, specialty media, and bioinformatics
- Knowledge about enabled technologies including biofuels, specialty chemicals, diagnostics, pharmaceuticals, and agriculture
- Analysis of the synthetic biology industry structure, competitors, and intellectual property landscape
- Assessment of the products and technologies most commercially viable in the immediate and near-future time frame.
- Comprehensive profiles of leading companies in the industry, including Active Motif, Bayer AG, BASF AG, Cargill Inc., Dowdupont Inc., Glaxosmithkline Plc, Merck KGAA, Novartis Pharma AG, Pfizer Inc. and Thermo Fisher Scientific Inc.


Chapter 1 Introduction
Study Goals and Objectives
Reasons for Doing the Study
Contribution of the Study and for Whom
Scope and Format
Methodology
Information Sources
Geographical Breakdown
Analysts Credentials
BCC Custom Research
Related BCC Research Reports
Chapter 2 Summary and Highlights
Chapter 3 Overview
Synthetic Biology Technologies Covered in this Report
Synthetic Biology Overview
Development Stage of Synthetic Biology
Forces Driving Synthetic Biology Market Growth
Global Markets for Synthetic Biology Products
Life Cycle Status of Products and Technologies
Synthetic Biology Industry
Chapter 4 Technology Background
Introduction
Synthetic Biology Defined
Synthetic Biology History
Paradigm Shift in Biology
Synthetic Biology Technology Overview
Enabling Technologies
DNA-Synthesis and DNA-Sequencing Cost Trends
DNA-Synthesis Technologies
Microfluidic Technologies
Next-Generation Sequencing Technologies
Gene Editing
Gene Drives
Bioinformatics Technologies
Biologic Components and Integrated Systems Technologies
Synthetic DNA
BioBrick Parts
Minimal Genomes and Chassis Organisms
Enabled Products
Pathway Engineering
Research and Development Applications
Synthetic Biology and the Microbiome
Synthetic Biology in Biofuels Feedstocks
Synthetic Biology Microbiome Initiatives
Chapter 5 Synthetic Biology Applications
Enabling Technologies Applications
Biologic Components and Integrated Systems Applications
Synthetic Genes
BioBrick Parts
Integrated Systems
Enabled Products Applications
Pharmaceuticals
Industrial Biotechnology Applications
Agricultural Applications
Data Storage Applications
Chapter 6 Synthetic Biology Industry
Industrial Biotechnology Value Chain
Industry Structural Forces
Products and Technology Life Cycle
Sequencing Instruments Industry
Long-Read Sequencing Industry
DNA Synthesis Industry
Oligos as Therapeutics
Gene Synthesis Workflow
Gene Synthesis Value Chain
Synthetic Gene Market Segments
Gene Editing Industry
Synthetic Biology Organism Design and Foundries Industry
Software Industry
Agriculture Industry
Consumer Products Industry
Cosmetics and Skin Care Industry
Food and Beverages Industry
Healthcare Industry
Industrial Chemicals Industry
Cell-Free Systems Industry
Industry Acquisitions and Strategic Alliances
Chapter 7 Synthetic Biology Markets
Industry Growth-Driving Forces
DNA Read, Write and Edit Technologies
Growing Role of Designer Organisms
Speeding up of Commercialization Pathways
Growth in Synthetic Biology Foundries
Synthetic Biology Markets by End-User Industry
Research Market
Healthcare Market
Industrial Chemicals Market
Agriculture Market
Consumer Market
Food and Beverage Market
Synthetic Biology Markets by Product Type
Enabling Products Markets
Biologic Components Market
Integrated Systems Market
Enabled Product Markets
Sources of Competitive Advantage
Healthcare Market
Consumer Products Market
Food and Beverage Market
Chemicals Market
Agriculture Market
Geographic Markets
Synthetic Biology Products by Region
Enabling Products Market by Region
Core Products Market by Region
Enabled Products Market by Region
Chapter 8 Patents
Introduction
Foundational Patents
Synthetic Biology Industry Patent Analysis
Sequencing-Related Patent Issues
Gene editing-Related Patents
Gene Editing Patents: Sangamo Case Study
Chapter 9 Company Profiles
20N LABS INC.
ABEONA THERAPEUTICS LLC
ACTIVE MOTIF
AEMETIS INC.
AGILENT TECHNOLOGIES INC.
AJINOMOTO CO. INC.
AGRIMETIS LLC
AGRIVIDA INC.
ALGENUITY
AMBRX INC.
AMFORA INC.
AMYRIS INC.
ANSA BIOTECHNOLOGIES INC.
ANTHEIA INC.
ARBOR BIOTECHNOLOGIES INC.
ARCADIA BIOSCIENCES INC.
ARCTURUS THERAPEUTICS INC.
ARDRA BIO INC.
ARZEDA CORP.
ASTRAZENECA PLC
ATG BIOSYNTHETICS GMBH
ATUM
AVECIA
AZARGEN BIOTECHNOLOGIES PTY LTD.
AZITRA INC.
BASF AG
BAYER AG
BEAM THERAPEUTICS INC.
BENCHLING
BENSON HILL BIOSYSTEMS INC.
BIO BASIC INC.
BIOCAPITAL HOLDINGS LLC.
BIOCELLECTION INC.
BIOGEN INC.
BIOMAX INFORMATICS AG
BIOMX LTD.
BIONEER CORP.
BIO S&T INC.
BIOSYNTIA APS
BLUEBIRD BIO INC.
B-MOGEN BIOTECHNOLOGIES INC.
BOLT THREADS INC.
BRISTOL-MYERS SQUIBB CO.
BROOKS LIFE SCIENCES
CALYSTA INC.
CALYXT INC.
CARGILL INC.
CARIBOU BIOSCIENCES INC.
CASEBIA THERAPEUTICS
CASZYME
CATALOG TECHNOLOGIES INC.
CELGENE CORP.
CELLECTIS SA
CELL-FREE TECHNOLOGY LTD.
CENTRIENT PHARMACEUTICALS
CHAIN BIOTECHNOLOGY LTD
CIBUS INC.
CLARA FOODS CO.
C-LECTA GMHB
CODAGENIX INC.
CODEXIS INC.
COLORIFIX LTD.
CORBION
CRONOS GROUP
CRISPR THERAPEUTICS AG
CROWN LABORATORIES INC.
DANAHER CORP.
DEMURIS LTD.
DESKTOP GENETICS LTD.
DNA SCRIPT
DOVETAIL GENOMICS LLC
DOWDUPONT INC.
EDIGENE CORP.
EDIGENE INC.
EDITAS MEDICINE INC.
EGENESIS INC.
ELIGO BIOSCIENCE SAS
ENDLESS WEST
ENEVOLV INC.
EPOCH LIFE SCIENCE INC.
ETAGEN PHARMA
EUROFINS SCIENTIFIC
EVONETIX
EVOLVA SA
EXPEDEON AG
EXXONMOBIL CORP.
GC INNOVATION AMERICA
G+FLAS LIFE SCIENCES INC.
GEA ENZYMES
GELTOR INC.
GENEMED SYNTHESIS INC.
GENERAY BIOTECH CO. LTD.
GENOMATICA
GENSCRIPT
GENUS PLC
GEVO INC.
GILEAD SCIENCES INC.
GINKGO BIOWORKS
GLAXOSMITHKLINE PLC
GLOBAL BIOENERGIES
GLOWEE
GLYCOSBIO FOOD SCIENCES
GLYCOSYN LLC
GOODYEAR TIRE & RUBBER CO.
GREEN BIOLOGICS LTD.
HELIXWORKS TECHNOLOGIES LTD.
HOMOLOGY MEDICINES INC.
HORIZON DISCOVERY GROUP PLC
HUVEPHARMA
ILLUMINA INC.
IMPOSSIBLE FOODS INC.
INDUSTRIAL MICROBES INC.
INGENZA LTD.
INOVIO PHARMACEUTICALS INC.
INSCRIPTA INC.
INTELLIA THERAPEUTICS INC.
INTERNATIONAL BUSINESS MACHINES
INTREXON CORP.
JOYN BIO
KANEKA CORP.
KWS SAAT SE
LABGENIUS LTD.
LANZATECH
LATTICE AUTOMATION INC.
LC SCIENCES
LCY CHEMICAL CORP.
LGC GROUP
LOCUS BIOSCIENCES
LOGICBIO THERAPEUTICS
LUMEN BIOSCIENCE
LYGOS INC.
MEISSA VACCINEC INC.
MERCK KGAA
MICROSYNBIOTIX
MICROBYRE INC.
MICROSOFT CORP.
MIRACULEX
MILIS BIO LTD.
MODERN MEADOW
MODULAR GENETICS INC.
MOLECULAR ASSEMBLIES INC.
MORPHOSYS AG
MOTIF INGREDIENTS
NEW ENGLAND BIOLABS
NOVARTIS PHARMA AG
NOVOME BIOTECHNOLOGIES INC.
NOVOZYMES A/S
NOVVI LLC
NUCELIS LLC
NUCLERA NUCLEICS LTD.
OMEGA BIO-TEK INC.
ORAGENICS INC.
OXFORD BIOMEDICA PLC
OXFORD GENETICS LTD.
PAIRWISE PLANTS INC.
PFIZER INC.
PHIO PHARMACEUTICALS CORP.
PHYLOGICA LTD.
PHYLUM BIOSCIENCES INC.
PHYTOWELT GREEN TECHNOLOGIES GMBH
PIVOT BIO
POSEIDA THERAPEUTICS INC.
PRECISION BIOSCIENCES INC.
PROKARIUM HOLDINGS LTD.
PROMEGA CORP.
PTC THERAPEUTICS, INC.
RECOMBINETICS, INC.
ROQUETTE FRERES
ROYAL DSM NV
SAMPLE6 TECHNOLOGIES
SANGAMO THERAPEUTICS INC.
SAREPTA THERAPEUTICS INC.
SCARAB GENOMICS LLC
SENTI BIOSCIENCES
SGI-DNA INC.
SHINEGENE MOLECULAR BIO-TECHNOLOGIES INC.
SIGMA ALDRICH CORP.
SHERLOCK BIOSCIENCES
SILICOLIFE LDA.
SOCATI CORP.
SPIBER INC.
STRING BIO
SUGARLOGIX
SYNBIOTA
SYNBIO TECHNOLOGIES INC.
SYNBIOBETA
SYNGENTA AG (CHEMCHINA)
SYNPROMICS LTD.
SYNTHEGO CORP.
SYNTHETIC GENOMICS INC.
SYNLOGIC THERAPEUTICS
SYNTHACE LTD.
SYNTHETIC BIOLOGICS INC.
SYNTHORX INC.
TAKARA BIO
TEEWINOT LIFE SCIENCES CORP.
TEPHA INC.
TESELAGEN BIOTECHNOLOGY INC.
THERMO FISHER SCIENTIFIC INC.
TIERRA BIOSCIENCES
TINCTORIUM BIO
TOOLGEN
TRANSCRIPTIC INC.
TRANSLATE BIO
TROPIC BIOSCIENCES UK LTD.
TWIST BIOSCIENCE
TRITON ALGAE INNOVATIONS LTD.
VEDANTA BIOSCIENCES
VERSALIS SPA
VERTEX PHARMACEUTICALS INC.
VIR BIOTECHNOLOGY INC.
XYPHOS INC.
YIELD10 BIOSCIENCES INC.
ZIOPHARM ONCOLOGY, INC.
ZYMERGEN
ZYMOCHEM INC.


List Of Tables


Summary Table : Global Synthetic Biology Market, by Product Type, Through 2024
Table 1 : Report Scope
Table 2 : Synthetic Biology Paradigm
Table 3 : Synthetic Biology Market Driving Forces, 2019 to 2024
Table 4 : Global Synthetic Biology Market, by End-User Industry, Through 2024
Table 5 : Synthetic Biology Products and Technology Life Cycle Stage
Table 6 : Synthetic Biology Industry, by Market Segment
Table 7 : Synthetic Biology Definitions
Table 8 : Synthetic Biology History, 1970–2019
Table 9 : Paradigm Shift Caused by Synthetic Biology
Table 10 : Comparison of Genetic Engineering and Synthetic Biology
Table 11 : Synthetic Biology Applications, by Technology
Table 12 : Importance of Enabling Technologies
Table 13 : Cost to Sequence a Single Human Genome, 2001-2019
Table 14 : DNA-Synthesis Costs, 2006–2019
Table 15 : Pros and Cons of Gene-Synthesis Technologies
Table 16 : Importance of Microfluidics Technologies in Synthetic Biology
Table 17 : Next-Generation Sequencing Technologies, by Company, 2019
Table 18 : Gene Editing Therapeutic Interventions
Table 19 : Gene Editing Technology Approaches
Table 20 : Comparison of the Major Gene Editing Technologies
Table 21 : Comparison of CRISPR Enzyme Technology
Table 22 : Potential Market Applications for Gene Drive Modified Organisms
Table 23 : Synthetic Biology Bioinformatics Technologies
Table 24 : Comparison of Nucleic Acids, Genes and Genomes
Table 25 : Synthetic DNA Types
Table 26 : Synthetic Genes as Molecular-Biology Tools
Table 27 : Synthetic Genes Versus Traditional Polymerase Chain Reaction Cloning
Table 28 : Mechanism of DNA Constructs
Table 29 : Key Attributes of a Minimal Genome
Table 30 : Enabled Technologies, by Near-Term Application
Table 31 : Metabolic Engineering for Artemisinic Acid
Table 32 : Research and Development Applications for Synthetic Biology Products
Table 33 : Microbiomes: Approaches of Incorporation of Synthetic Biology
Table 34 : Contribution of Synthetic Biology to Biofuels
Table 35 : Synthetic Biology Initiatives Relating to the Microbiome
Table 36 : Synthetic Biology Products Impacted by Enabling Technologies
Table 37 : Biologic Components and Integrated Systems Near-Term Applications
Table 38 : Synthetic Genes Near-Term Applications, by End User
Table 39 : E Coli as a Chassis Organism
Table 40 : Drug Discovery and Development Applications for Synthetic Biology Products
Table 41 : Gene Editing Clinical Pipeline, by Company, 2019
Table 42 : CAR-T Cell Alliances and Synthetic Biology Platforms
Table 43 : Industrial Biotechnology Applications
Table 44 : Synthetic Biology Enabled Biofuel Applications
Table 45 : Growth Status of Specialty Versus Drop-in Biofuels, 2000-2020
Table 46 : Synthetic Biology Enabled Agriculture and Animal Applications
Table 47 : U.S. and European Approaches to Regulation of Gene Edited Crops
Table 48 : Synthetic Biology Industry Structural Forces
Table 49 : Synthetic Biology Products and Technology Life Cycle Stage
Table 50 : Advanced Sequencing Industry Company Positioning, 2019
Table 51 : End-to-End Sequencing Approaches
Table 52 : Long-Read Sequencing Industry, by Company, 2019
Table 53 : Nucleic Acid Synthesis Key Competitor Strategies, by Company, 2019
Table 54 : RNA Therapy Segments
Table 55 : RNA Therapies Industry
Table 56 : Gene Synthesis Workflow
Table 57 : Gene Synthesis Market Factors of Differentiation
Table 58 : Gene Editing Industry, 2019
Table 59 : Regulatory Situation of Gene-Edited Crops, by Country or Region
Table 60 : Clinical-Stage Gene Editing Industry, 2019
Table 61 : Competitive Platforms: ?-Thalassemia
Table 62 : Competitive Platforms: LCA, 2019
Table 63 : Organism Design and Automation Industry, 2019
Table 64 : Market Focus for Selected Synthetic Biology Software Companies, 2019
Table 65 : Market Segment of Synthetic Biology Agriculture Industry, by Company, 2019
Table 66 : Market Segment of Consumer Products Industry, by Company, 2019
Table 67 : Cosmetics and Skin Care Industry, 2019
Table 68 : Food and Beverage Industry, 2019
Table 69 : Synthetic Biology-Based Healthcare Industry, 2019
Table 70 : Microbiome Therapeutics Industry, 2019
Table 71 : Synthetic Biology-Based Industrial Chemicals Industry, 2019
Table 72 : Leading Companies in the Cell-Free Synthetic Biology Industry, 2019
Table 73 : Synthetic Biology Industry Acquisitions, January 2018-September 2019
Table 74 : Strategic Alliances, January 2018–September 2019
Table 75 : Forces Driving Growth in the Synthetic Biology Markets
Table 76 : Global Synthetic Biology Market in Research Applications, by Product Type, Through 2024
Table 77 : Global Synthetic Biology Market in Healthcare Applications, by Product Type, Through 2024
Table 78 : Global Synthetic Biology Market for Industrial Chemical Applications, by Product Type, Through 2024
Table 79 : Global Synthetic Biology Market for Agricultural Applications, by Product Type, Through 2024
Table 80 : Global Synthetic Biology Market in Consumer Applications, by Product Type, Through 2024
Table 81 : Global Synthetic Biology Market for Food and Beverage Applications, by Product Type, Through 2024
Table 82 : Global Synthetic Biology Market, by Product Type, Through 2024
Table 83 : Global Synthetic Biology Enabling Product Market, by Type, Through 2024
Table 84 : Global Synthetic Biology Enabling Products Market, by End-User Industry, Through 2024
Table 85 : Global Synthetic Biologic Components Market, by Type, Through 2024
Table 86 : Global Synthetic Biologic Components Market, by End-User Industry, Through 2024
Table 87 : lobal Synthetic Biology Integrated Systems Market, by Type, Through 2024
Table 88 : Synthetic Biology Microbe Engineering Workflow
Table 89 : Global Synthetic Biology Integrated Systems Market, by End-User Industry, Through 2024
Table 90 : Biodiesel Fuel Performance Comparison
Table 91 : Artemisinin Drug Production Comparison
Table 92 : Sweetener Product Comparison
Table 93 : Global Synthetic Biology Enabled Products Market, by End-User Industry, Through 2024
Table 94 : Global Synthetic Biology Healthcare Market, by Sector, Through 2024
Table 95 : Global Synthetic Biology Gene editing Therapeutic Market, by Disease Category, Through 2024
Table 96 : Gene Editing Clinical Pipeline, by Company, 2019
Table 97 : Global Synthetic Biology Consumer Products Market, by Type, Through 2024
Table 98 : Global Synthetic Biology Food and Beverage Market, by Type, Through 2024
Table 99 : Factors for Synthetic Biology-Based Chemical Processes
Table 100 : Global Synthetic Biology Industrial Chemicals Market, by Product Type, Through 2024
Table 101 : Advanced Biofuel Growth Factors
Table 102 : Crude Oil Prices, 2011-2019
Table 103 : Strategic Shifts in Biofuels, by Company, 2017 and 2018
Table 104 : Global Synthetic Biology Agriculture Market, by End-User Industry, Through 2024
Table 105 : Global Synthetic Biology Agriculture Animals Market, by Application, Through 2024
Table 106 : Mosquito-Control Methods
Table 107 : Aedes Aegypti Initial Markets, 2019
Table 108 : Global Synthetic Biology Crop Enhancement Market, by Crop Type, Through 2024
Table 109 : Advantages of Gene Editing for Crop Enhancement
Table 110 : Gene-Edited Crop Market Landscape
Table 111 : Gene Edited Crops Commercialization Pathway
Table 112 : Global Synthetic Biology Market, by Region, Through 2024
Table 113 : Global Synthetic Biology Enabling Product Market, by Region, Through 2024
Table 114 : Global Synthetic Biology Core Products Market, by Region, Through 2024
Table 115 : Global Synthetic Biology Enabled Products Market, by Region, Through 2024
Table 116 : Synthetic Biology Patent Scope
Table 117 : Synthetic Biology Foundational Patents
Table 118 : Synthetic Biology Representative Patent Grouping, by Tier
Table 119 : Patent Description, by Company
Table 120 : Status of Liquid Biopsy and Sequencing-Related Patent Disputes, 2019
Table 121 : CRISPR-Cas9 Patent Groups
Table 122 : CRISPR-Cas9 Patent Licensing Fields, by Company
Table 123 : Sangamo Collaboration Agreements Relating to ZFN Technology
Table 124 : Sangamo Therapeutics Patent Position
Table 125 : Agrivida Technical Approach
Table 126 : Ginkgo Bioworks Engineered-Organism Workflow
Table 127 : Gene Editing Versus Gene Therapy Approach


List Of Figures


Summary Figure : Global Synthetic Biology Market, by Product Type, 2017-2024
Figure 1 : Synthetic Biology Value Added Chain
Figure 2 : Evolution of Synthetic Biology from Natural to Artificial Systems
Figure 3 : Conventional versus Synthetic Biology Approach to Gene Synthesis
Figure 4 : Scale of Synthetic Biology
Figure 5 : Schematic of Conventional DNA-Synthesis Technologies
Figure 6 : Microarrays in DNA Synthesis
Figure 7 : Roles of Promoters and Reporters in Synthetic Biology Systems
Figure 8 : Creation of Enabled Products Through Synthetic Biology
Figure 9 : Industrial Biotechnology Value Chain with Synthetic Biology Leverage Points


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