Summary

The Vaccine Partnering Terms and Agreements report provides comprehensive understanding and unprecedented access to the vaccine partnering deals and agreements entered into by the worlds leading healthcare companies.

Trends in vaccine and adjuvant partnering deals
Deal terms analysis
Partnering agreement structure
Partnering contract documents
Top deals by value
Most active dealmakers
Average deal terms for vaccines

Description

The Vaccine Partnering Terms and Agreements report provides comprehensive understanding and unprecedented access to the vaccine partnering deals and agreements entered into by the worlds leading healthcare companies.

The report provides a detailed understanding and analysis of how and why companies enter vaccine partnering deals. The majority of deals are discovery or development stage whereby the licensee obtains a right or an option right to license the licensors vaccine technology. These deals tend to be multicomponent, starting with collaborative R&D, and commercialization of outcomes. The report also includes adjuvant deals and alliances.

Understanding the flexibility of a prospective partner’s negotiated deals terms provides critical insight into the negotiation process in terms of what you can expect to achieve during the negotiation of terms. Whilst many smaller companies will be seeking details of the payments clauses, the devil is in the detail in terms of how payments are triggered – contract documents provide this insight where press releases do not.

This report contains over 1,500 links to online copies of actual vaccine deals and contract documents as submitted to the Securities Exchange Commission by companies and their partners. Contract documents provide the answers to numerous questions about a prospective partner’s flexibility on a wide range of important issues, many of which will have a significant impact on each party’s ability to derive value from the deal.

The initial chapters of this report provide an orientation of vaccine dealmaking and business activities. Chapter 1 provides an introduction to the report, whilst chapter 2 provides an overview of the trends in vaccine dealmaking since 2007, including details of average headline, upfront, milestone and royalty terms.

Chapter 3 provides a review of the leading vaccine deals since 2007. Deals are listed by headline value, signed by bigpharma, most active bigpharma, and most active of all biopharma companies. Where the deal has an agreement contract published at the SEC a link provides online access to the contract.

Chapter 4 provides a comprehensive listing of the top 50 bigpharma companies with a brief summary followed by a comprehensive listing of vaccine deals as well as contract documents available in the public domain. Where available, each deal title links via Weblink to an online version of the actual contract document, providing easy access to each contract document on demand.

Chapter 5 provides a comprehensive and detailed review of vaccine partnering deals signed and announced since 2007, where a contract document is available in the public domain. The chapter is organized by company A-Z, stage of development at signing, deal type (collaborative R&D, co-promotion, licensing etc), and specific therapy focus. Each deal title links via Weblink to an online version of the deal record and where available, the contract document, providing easy access to each contract document on demand.

The report also includes numerous tables and figures that illustrate the trends and activities in vaccine partnering and dealmaking since 2007.

In conclusion, this report provides everything a prospective dealmaker needs to know about partnering in the research, development and commercialization of vaccine technologies and products.

Vaccine Partnering Terms and Agreements is intended to provide the reader with an in-depth understanding and access to vaccine trends and structure of deals entered into by leading companies worldwide.

Vaccine Partnering Terms and Agreements includes:

Trends in vaccine dealmaking in the biopharma industry since 2007
Analysis of vaccine deal structure
Access to headline, upfront, milestone and royalty data
Case studies of real-life vaccine deals
Access to over 1,500 vaccine deal documents
The leading vaccine deals by value since 2007
Most active vaccine dealmakers since 2007
The leading vaccine partnering resources
In Vaccine Partnering Terms and Agreements, the available contracts are listed by:

Company A-Z
Headline value
Stage of development at signing
Deal component type
Specific therapy target
Each deal title links via weblink to an online version of the deal record and where available, the contract document, providing easy access to each contract document on demand.

The Vaccine Partnering Terms and Agreements report provides comprehensive access to available deals and contract documents for over 1,500 vaccine deals. Analyzing actual contract agreements allows assessment of the following:

What are the precise vaccine rights granted or optioned?
What is actually granted by the agreement to the partner company?
What exclusivity is granted?
What is the payment structure for the deal?
How are sales and payments audited?
What is the deal term?
How are the key terms of the agreement defined?
How are IPRs handled and owned?
Who is responsible for commercialization?
Who is responsible for development, supply, and manufacture?
How is confidentiality and publication managed?
How are disputes to be resolved?
Under what conditions can the deal be terminated?
What happens when there is a change of ownership?
What sublicensing and subcontracting provisions have been agreed?
Which boilerplate clauses does the company insist upon?
Which boilerplate clauses appear to differ from partner to partner or deal type to deal type?
Which jurisdiction does the company insist upon for agreement law?

Benefits

Vaccine Partnering Terms and Agreements provides the reader with the following key benefits:

In-depth understanding of vaccine and adjuvant deal trends since 2007
Access to headline, upfront, milestone and royalty data
Analysis of the structure of vaccine agreements with numerous real life case studies
Comprehensive access to over 1500 actual vaccine contracts entered into by the world’s biopharma companies
Detailed access to actual vaccine contracts enter into by the leading fifty bigpharma companies
Insight into the terms included in a vaccine agreement, together with real world clause examples
Understand the key deal terms companies have agreed in previous deals
Undertake due diligence to assess suitability of your proposed deal terms for partner companies

Executive Summary
 
 Chapter 1 – Introduction
 
 Chapter 2 – Trends in vaccine dealmaking
 
 2.1. Introduction
 2.2. Companion vaccine over the years
 2.3. Bigpharma vaccine dealmaking activity
 2.4. Bigpharma not active in vaccines
 2.5. Vaccine partnering by deal type
 2.6. Vaccine partnering by disease type
 2.7 Average deal terms for vaccine
 2.7.1 Vaccine headline values
 2.7.2 Vaccine upfront payments
 2.7.3 Vaccine milestone payments
 2.7.4 Vaccine royalty rates
 Chapter 3 – Leading vaccine deals
 
 3.1. Introduction
 3.2. Top vaccine deals by value
 3.3. Top vaccine deals involving bigpharma
 Chapter 4 – Bigpharma vaccine deals
 
 4.1. Introduction
 4.2. How to use bigpharma vaccine partnering deals
 4.3. Bigpharma vaccine partnering company profiles
 Abbott
 Actavis
 Alcon Labs
 Allergan
 Amgen
 Apotex
 Astellas
 AstraZeneca
 Baxter International
 Bayer
 Biogen Idec
 Boehringer Ingelheim
 Bristol-Myers Squibb
 Celgene
 Cephalon
 Chugai
 CSL
 Daiichi Sankyo
 Dainnipon Sumitomo
 Eisai
 Eli Lilly
 Forest Laboratories
 Genzyme
 Gilead Sciences
 GlaxoSmithKline
 Hospira
 Johnson & Johnson
 Kyowa Hakko Kirin
 Lundbeck
 Menarini
 Merck & Co
 Merck KGaA
 Mitsubishi-Tanabe
 Mylan
 Novartis
 Novo Nordisk
 Nycomed
 Otsuka
 Pfizer
 Roche
 Sanofi
 Servier
 Shionogi
 Shire
 Stada
 Takeda
 Teva
 UCB
 Warner Chilcott
 Watson
 Chapter 5 – Vaccine dealmaking directory
 
 5.1. Introduction
 5.2. Company A-Z
 5.3. By stage of development
 Discovery
 Pre-clinical
 Phase I
 Phase II
 Phase III
 Registration
 Marketed
 5.4. By deal type
 Asset and product purchase
 Collaborative R&D
 Co-development
 Co-marketing
 Co-promotion
 Development
 Distribution
 Evaluation
 Joint venture
 Licensing
 Manufacturing
 Marketing
 Option
 Promotion
 Research
 Supply
 5.5. By therapy area
 Hospital care
 Cardiovascular
 Central nervous system
 Dental
 Dermatology
 Gastrointestinal
 Genetic disorders
 Genitourinary
 Hematology
 Genetic disorders
 Immunology
 Infection
 Inflammatory
 Metabolic
 Musculoskeletal
 Oncology
 Ophthalmics
 Respiratory
 Sensory organ
 Animal health
 5.6. By related technology
 Adjuvants
 Drug delivery
 Chapter 6 – Partnering resource center
 
 6.1. Online partnering
 6.2. Partnering events
 6.3. Further reading on dealmaking
 Appendices
 
 Appendix 1 – Deal type definitions
 Appendix 2 – Example vaccine partnering agreement
 About Wildwood Ventures
 
 Figures in report
 
 Figure 1: Vaccine partnering since 2007
 Figure 2: Bigpharma – top 50 – vaccine deals 2007 to 2011
 Figure 3: Inactive bigpharma in vaccine 2007-2011
 Figure 4: Vaccine partnering by deal type since 2007
 Figure 5: Vaccine partnering by disease type since 2007
 Figure 6: Vaccine partnering by infectives target since 2007
 Figure 7: Vaccine partnering by oncology target since 2007
 Figure 8: Vaccine deals with a headline value
 Figure 9: Vaccine deal headline value distribution, US$million
 Figure 10: Vaccine deal headline value distribution, US$million
 Figure 11: Vaccine deals with upfront payment values
 Figure 12: Vaccine deal upfront payment distribution, US$million
 Figure 13: Vaccine deals with milestone payments
 Figure 14: Vaccine deal milestone payment distribution, US$million
 Figure 15: Vaccine deals with royalty rates, %
 Figure 16: Vaccine deal royalty rate distribution, %
 Figure 17: Top vaccine deals by value since 2007
 Figure 18: Top vaccine deals signed by bigpharma value since 2007
 Figure 19: Online partnering resources
 Figure 20: Forthcoming partnering events
 Figure 21: Deal type definitions
 Figure 22: Vaccine partnering agreement between Novavax and LG Life Sciences, March 2011