I. SCOPE AND METHODOLOGY
II.REPORT SYNOPSIS
General Definitions
Myoblasts
Pluripotent Cells
Multipotent Cells
Progenitor Cells
Role of Stem Cells in Repairing the Heart
Stem Cell Therapy
Stem Cells in Cardiology
Cell Based Myocardial Repair
Cord Blood Stem Cells in Regenerative Medicine
Cardiocytes
Coronary Angiography
Cardiovascular Diseases
Major Common Causes of CHD
Myocardial Infarction
Symptoms of MI
Risk Factors
Possible Therapies to Treat MI
Adult Stem Cells in Myocardial Infarction
Mobilized Stem Cells in Treating Myocardial Infarction
Congestive Heart Failure
Left-Sided Failure
Right-Sided Failure
Myocardial Rupture
Risk Factors
Classification of Myocardial Rupture
Symptoms of Myocardial Rupture
Treatment of Myocardial Rupture
Cardiomyopathy
Systemic Disease Causing Cardiomyopathy
Extrinsic Cardiomyopathy
Ischemic Cardiomyopathy
Symptoms of Ischemic Cardiomyopathy
Cord Blood Cells to Treat Ischemia
Intrinsic Cardiomyopathy
Dilated Cardiomyopathy or DCM
Hypertrophic Cardiomyopathy
Arrhythmogenic Right Ventricular Cardiomyopathy
Restrictive Cardiomyopathy
Non Compaction Cardiomyopathy
Malignant Cardiomyopathy/Accelerated Cardiomyopathy
Signs and Symptoms
Treatment
Coronary Heart Disease
Symptoms of Angina Pectoris
Kinds of Angina
Stable Angina
Unstable Angina
Hypertensive Heart Disease
Symptoms
Valvular Heart Disease
Types of Valvular Diseases
Inflammatory Heart Disease
Stem Cells - Cardiology
Bone Marrow Stem Cells
Mononuclear Bone Marrow (MNBM) Stem Cells
Heart Muscle Regeneration with Bone Marrow Stem Cells
Introduction
Adult Stem Cells
Haematopoietic Stem Cells
Mesenchymal Stem Cells
Endothelial Progenitor Cells
Myoblast Cells
Fetal Cardiomyocytes
Stem Cell Delivery
Autologous Stem Cells
Autologous Skeletal Myoblasts
Delivery of Autologous Myoblasts by Catheter
Functional Assessment of Stem Cell Therapy
Segmentation of Stem Cells in Cardiology
Exhibit 1: Segmentation of Global Stem Cells Market in Cardiology by Source (Allogenic and Autogenic) and by Type (Bone Marrow Stem Cells, Embryonic Stem Cells and Other*)
Stem Cells - Global Market Analysis
Exhibit 2: Stem Cells - Global Value Market Estimations & Predictions (2005 -2015) in US$ Million Stem Cells in Cardiology - Global Market Analysis
Exhibit 3: Stem Cells in Cardiology - Global Value Market Estimations & Predictions (2005 -2015) in US$ Million
Exhibit 4: List of Major Global Companies
III. MARKET DYNAMICS
I. Global Market Analysis
Exhibit 5: Stem Cells - Global Value Market Estimations & Predictions (2005 -2015) by Geographic Region for North America, Europe, Asia-Pacific and Rest of World in US$ Million
Exhibit 6: Stem Cells - Global Value Market Shares (2009 & 2015) by Geographic Regions by North America, Europe, Asia-Pacific and Rest of World
2. Market Overview
Exhibit 7: Stem Cells in Cardiology - Global Value Market Estimations & Predictions (2005 -2015) in US$ Million
3. Market Trends
Israel Leads in Stem Cell Based Research
Treating Heart Diseases with Stem Cells
Cord Blood Stem Cells Based Therapies for Diseases of the Heart and Blood Vessels
Cord Blood Stem Cell Therapies for Enhancing the Performance of Heart’s Ventricles, and
Repairing Arteries and Veins
Effectiveness of Cord Blood Stem Cells for Treating Congenital Heart Problems
Effectiveness of Cord Blood Stem Cells Based Therapies for Treating Peripheral Vascular Disease
Outlook for Cord Blood Stem Cells Based Medical Therapies
Inactivation of P66sch Gene Provides a Solution to Rapid Aging of Stem Cells in the Heart, and Higher Risk of Heart Failure, Caused by Diabetes
Mesenchymal Stem Cells from Bone Marrow Prompts Angiogenesis and Bring in Changes
in Diabetic Cardiomyopathy
Endothelial Progenitor Cells for Vascular Repairs
Treating Cardiovascular Diseases with Endothelial Progenitor Cells
Transplanted Fetal Cardiomyocytes Effective as Pacemaker in the Heart
Adult Bone Marrow Stem Cells Used for Reproducing Myocardium in Case of Ischemic
Heart Disease
Multipotent Meso-Angioblast Collected from Dorsal Aorta is Capable of Self-Renewal, and
Transformation into Majority of Cells Forming Mesodermal Tissues
4. Major Companies - Stem Cells in Cardiology
Aastrom Biosciences, Inc. (USA)
Advanced Cell Technology, Inc. (USA)
Aldagen, Inc. (USA)
Athersys, Inc. (USA)
Axordia Ltd. (UK)
Baxter International (USA)
Bioheart, Inc. (USA)
More……….
5. Major Product Innovations/Launches in Stem Cell Research - Cardiology
GSK and HSCI in Research Collaboration for Stem Cells
Gamida Cell and Biologics Delivery Systems in Collaboration Agreement
PerkinElmer Establishes Stem Cell Research Center
Geron Reports Positive Results for Embryonic Stem Cell Therapy for Heart Failure
New Type of Stem Cells Discovered on Epicardium by Scientists
Aastrom Starts Phase II Clinical Trials Using Cells from Patient’s Own Bone Marrow to
Treat Chronic Heart Failure
Angioblast Systems Gets FDA Approval for Phase 2 Trial
Pluristem Therapeutics Qualified as a Good Manufacturing Practices (GMP) Site for the
More……..
6. Regional Market Analysis
A. NORTH AMERICA
The President's Criteria
The Role of the NIH
The US Backs Stem Cell Research
Exhibit 8: Prevalence of Cardiovascular Diseases – 2005 in the US
Exhibit 9: US Death Rates for Cardiovascular and Non-Cardiovascular Disease
Market Analysis
Exhibit 10: Stem Cells in Cardiology - North American Value Market Estimations & Predictions (2005 -2015) in US$ Million
Exhibit 11: List of Major Companies in North America
B. EUROPE
Funding for Stem Cell Research in Europe
Exhibit 12: Cardiovascular Disease: Death Statistics in Europe
Exhibit 13: Death Statistics by Cause in Europe
Exhibit 14: Rates of Hospital Discharges due to Cardiovascular Diseases -
2002-2005 in Europe
Market Analysis
Exhibit 15: Stem Cells in Cardiology - European Value Market Estimations & Predictions (2005 -2015) in US$ Million
Exhibit 16: List of Major Companies in Europe
C. ASIA-PACIFIC
Exhibit 17: Death Statistics for Cardiovascular Disease in Asia-Pacific
Market Analysis
Exhibit 18: Stem Cells in Cardiology - Asia-Pacific Value Market Estimations & Predictions (2005 -2015) in US$ Million
Exhibit 19: List of Major Companies in Asia-Pacific
D. REST OF WORLD
Exhibit 20: Death Statistics for Cardiovascular Disease in Rest of World
Market Analysis
Exhibit 21: Stem Cells in Cardiology - Rest of World Value Market Estimations & Predictions (2005 -2015) in US$ Million
Exhibit 22: List of Major Companies in Rest of World
IV. PRODUCT/TECHNOLOGY RESEARCH
1. Introduction
Cardiac Stem Cells
Biology of Stem Cells
Sources of Stem cells
Allogenic Stem Cell Transplantation
Autologous Stem Cell Transplantation
Exhibit 23: Stem Cells Market in Cardiology by Source - Global Value Market Estimations & Predictions (2005 -2015) for Allogenic and Autogenic Stem Cell Transplantation in US$ Million
Exhibit 24: Stem Cells Market in Cardiology by Source - Global Value Market Shares (2009 & 2015) by Source for Allogenic and Autogenic Stem Cells
Autologous Products and their Allogenic Counterparts - Manufacturing Risks, Product Development and Business Models
Stem Cells as Therapeutics
The Ideal Cell Types for Cardiac Stem Cell Therapy
Embryonic Stem Cells
Embryonic Stem Cells for Treating Cardiovascular Diseases
Lineage Specific Differentiation of Embryonic Stem Cells
Induction of Cardiogenesis in Embryonic Stem Cells- Via Down regulation of Notch1
Gene Signaling
Transformation of Embryonic Stem Cells into Cardiomyocytes
Cardiomyocytes from Human Embryonic Stem Cells
Stem Cells in Mitochondrial Faults and Toxicology
Cord Blood Stem Cells in Treating Heart Diseases
Exhibit 25: Stem Cells in Cardiology by Type - Global Value Market Estimations & Predictions (2005 -2015) for Bone Marrow Stem Cells, Embryonic Stem Cells and Other in US$ Million
Exhibit 26: Stem Cells in Cardiology - Global Value Market Shares (2009 & 2015) by Type for Bone Marrow Stem Cell, Embryonic Stem Cell and Other
Adult Stem Cells in Treating Heart Diseases
Introduction
Adult Stem Cell Therapy Improves Cardiac Function and Blood Flow
Mesenchymal Stem Cells in Treating Heart Disease
Transformation of Mesenchymal Stem Cells into Cardiovascular Tissue Cells
Human Cord Blood Mesenchymal Stem Cells
Bone Marrow-Derived Stem Cells (BMSC) Administered through Intra-myocardial Injection
Clinical Studies with Selected Bone Marrow Stem Cells
Other Research Studies
Gene Based Stem Cell Therapy
Catheter - Device for Cardiac Stem Cell Delivery
Uses
Catheter Implantation
Techniques of Stem Cell Delivery
Transvascular Method
Transendocardial Approach
Transepicardial Approach
Stem Cell Mobilization to the Injured Myocardium
Stem Cell Imaging
Cell Tracking by Use of Noninvasive Imaging
Direct Labeling of Cells by Making Use of Magnetic Resonance Agents
The Drawbacks of Magnetic Labeling
Direct Labeling of Cells Using Radionuclides
Nanoparticle Labeling
Reporter Genes for Cardiovascular Cell Imaging
The Future Prospects of Stem Cell Imaging
Imaging to Assess the Functional Effects of Cell therapy
Myocardial Perfusion
Cell Therapy Issues
Inconsistencies
Cardiac Stem Cell Therapy with Emphasis on Certain Issues Yet to be Resolved
Clinical Issues Involved in Cardiac Cell-Repair Therapy
Disadvantages of Stem Cell Therapy in Cardiovascular Diseases
Stem Cell Research and Regulatory Issues - A Summary
Cardiac Muscle Regeneration
Concerns Regarding Cell Therapy
The Principles of Stem Cell Research, Legal and Other Social Issues
The Science of Stem Cells
Embryonic Stem Cell Research in the UK
Regulations Regarding Research on Embryo and Embryonic Stem Cells in the UK
European Regulations
International Regulation of Stem Cell Research
Related Issues in Stem Cell Research
Embryonic Stem Cell Research and Related Issues
Regulation of Product Development
The EU Tissue Directive
Tissue Traceability and Donor Confidentiality
Achieving Patient Trust in Stem Cell Therapy
Intellectual Property Rights
Intellectual Property Rights in the United Kingdom
Intellectual Property Rights in Europe
Opportunity Costs, Resource Allocation and Equity
Longevity, Immortality and Individual Identity
2. Stem Cells in Cardiology – The Outlook
V. CORPORATE DIRECTORY
VI. PATENTS INFORMATION