The life science informatics marketplace--known as bioinformatics--is set to expand as high-tech companies infiltrate this arena and biopharmaceutical companies incorporate key informatic solutions into their business strategies. This Publications believes that many of the segments of bioinformatics described in this report offer an unusual opportunity for accelerated expansion within the coming years. This study is arranged to provide an overview of bioinformatics market segments and offer evidence that these segments are poised for significant future growth. Each segment is accompanied by analysis and forecasts by product type and application. This analysis surveys the bioinformatics market and the latest information regarding emerging new products and industry trends. The study will quantify and qualify the bioinformatics market segments as an area of research, product development and investment. Forecasts of the bioinformatics market and an analysis of products in the worldwide information-processing market will provide a basis for understanding the significance of past developments and future possibilities within this market category.

1. Overview 8
1.1 Statement of Report 8
1.2 About this Report 8
1.3 Scope of this Report 10
1.4 Methodology 10
1.5 Executive Summary 11

2. Introduction 13
2.1 Global Bioinformatics Products Industry 14
2.2 Computers and Biology 15
2.3 Bioinformatics and the Internet 17
2.4 Company Evaluation Overview 17
2.5 Market Outlook 18
2.6 Competitive Structure 20
2.7 Applications of Bioinformatics 20
2.7.1 Medicine 20
2.7.2 Microbial Genomics 22
2.7.3 Agriculture 22
2.8 R&D 22
2.8.1 Allocation of R&D 23
2.8.2 Traditional Drug Discovery Process 24
2.8.3 Drug Discovery and Bioinformatics 26
2.8.4 Collaborative Agreements 27
2.9 The Human Genome Project (HGP) 27
2.9.1 Goals of the Human Genome Project 27
2.9.2 Benefits of the Human Genome Project 29
2.10 Barriers to Entry 29
2.11 Proteomics and Databases 30
2.11.1 Protein Database Standards 31
2.11.2 Future Trends 32

3. The U.S. Bioinformatics Market 33
3.1 Overview 33
3.2 Market Restraints and Drivers 35
3.2.1 Market Restraints 35
3.2.2 Market Drivers 36

4. Genomics 37
4.1 The Biotechnology Industry 37
4.2 The Development of a Genomics Market 39
4.2.1 Market Drivers 40
4.2.2 Market Restraints 40
4.2.3 Market Size and Growth Projections 40
4.2.4 The U.S. Genomics Market 40
4.3 Biochips and DNA Microarrays 40
4.3.1 Key Challenges 42
4.3.2 Freeware 42
4.3.3 New Tools 43
4.4 Bioinformatics 46
4.5 Disease Targets 46
4.6 Functional Genomics 47
4.7 Gene Sequencing 50
4.8 Gene Sequence Variation Detection 50
4.9 Comparative Genomics 51
4.10 Genome Database Arrays 51
4.11 High-throughput Genomics 53
4.11.1 High-throughput Technology 54
4.11.2 Lab on a Chip 54
4.12 Pharmacogenomics 55
4.13 Probe Arrays 57
4.13.1 Gene Expression Monitoring Arrays 57
4.13.2 DNA Analysis Arrays 59
4.14 Proteomics 60
4.15 Sequencing 61
4.16 Single Nucleotide Polymorphisms (SNPs) 61
4.17 Structural Genomics 63
4.18 Photolithography 63
4.19 Instrumentation 64

5. The Bioinformatics Industry 65
5.1 Definition and Role of Bioinformatics 65
5.1.1 Bioinformatics Sector Overview 66
5.1.2 The Future Status of Bioinformatics 67
5.1.3 Barriers to Growth 67
5.2 Types of Data and Bioinformatics Applications 67
5.2.1 Validated Core Modeling Technology 68
5.2.2 Broad Applicability 69
5.2.3 Data Management Compliant with Industry Standards 69
5.2.4 Open Architecture 69
5.2.5 Ease of Use 69
5.2.6 Increased Access 69
5.3 Functions of Bioinformatics Software 70
5.3.1 Data Management 70
5.3.2 Data Transformation 70
5.3.3 Data Collaboration 70
5.3.4 Interface for Online Data Sources 70
5.4 Target Markets for Informatics Software 71
5.5 Steps Involved in Bringing a Drug to Market 71
5.6 Costs Incurred in Developing a New Drug 72
5.7 Industry Drivers and Challenges 72
5.8 Industry Risks 74
5.9 Products of Bioinformatics 75
5.10 Bioinformatics Processes 76
5.11 Informatics Tools and Functionalities 76
5.11.1 Sequence to Structure 76
5.11.2 Lead Identification and Optimization 77
5.11.3 Development and Formulation 77
5.11.4 Improving Materials and Processes 77
5.11.5 Other Materials-Based Industries 78
5.12 Role of Bioinformatics in the Biotechnology Value Chain 78
5.13 Bioinformatics Market Segment 78
5.13.1 Databases 78
5.13.2 Hardware 80
5.13.3 Software 80
5.13.4 Bioinformatics Services 81
5.14 Bioinformatics Market Size 82
5.14.1 Sales and R&D 82
5.14.2 IT Budget 83
5.14.3 Projected Bioinformatics Market Size 84
5.15 Global Market Perspective 85

6. Bioinformatics Business 88
6.1 Bioinformatics Business Models 88
6.1.1 Changing Business Models 89
6.1.2 Competition for Pure Play Informatics Companies 91
6.1.3 Non-Profit Organizations 91
6.1.4 In-House Bioinformatics Solutions 91
6.1.5 Large IT Companies 91
6.2 Bioinformatics Target Disciplines 92
6.2.1 Comparative Genomics 92
6.2.2 Pharmacogenomics 92
6.2.3 Functional Genomics 92
6.2.4 Proteomics 93
6.2.5 Structural Genomics 94
6.2.6 Image Informatics 94
6.2.7 Clinical Trial Informatics 95
6.2.8 Cheminformatics 95
6.3 Bioinformatics Architecture 96
6.4 Bioinformatics Applications 97
6.4.1 Data Search Tools 97
6.4.2 Data Visualization Tools 97
6.4.3 Data Mining and Clustering 98
6.4.4 Enterprise Solutions 99
6.4.5 Data Warehousing 99
6.5 Evaluation of Bioinformatics Solutions 99
6.5.1 Requirements of Study 99
6.5.2 Shortlisting the Options 99
6.5.3 Scoring Patterns 100
6.5.4 Performance 101
6.5.5 Data Storage 101
6.5.6 Data Management in Drug Discovery 102
6.5.7 Key Issues in Bioinformatics Data Storage 102
6.6 Convergence of Industries 103
6.7 Proteins as a Driver 104
6.8 Current Bioinformatics Research 104
6.9 New Bioinformatics Modeling Algorithms 105
6.10 3D Modeling 105
6.11 Patenting Bioinformatics Algorithms 106
7. Recent Industry Activity 109
7.1 Collaborations and Acquisitions 109
7.2 Product Development and Launches 111

8. Corporate Profiles 114
8.1 Abbott Laboratories 114
8.2 Abgenix 114
8.3 Ablynx 115
8.4 Accelrys 115
8.5 Affimed Therapeutics 117
8.6 Affitech 118
8.7 Affymetrix 118
8.8 Agencourt Bioscience Corporation 119
8.9 Agensys 120
8.10 Agilent Technologies 120
8.11 Alexion Pharmaceuticals 121
8.12 AlgoNomics 121
8.13 ALLEZ Software 122
8.14 Amgen 123
8.15 Antisoma 124
8.16 Applied Biosystems 124
8.17 Arana Therapeutics 126
8.18 Ariadne Genomics 127
8.19 Array Genetics 127
8.20 Astellas Pharma 128
8.21 AstraZeneca 128
8.22 Automated Handling Systems 129
8.23 Avesthagen, Limited 130
8.24 Bioalma 130
8.25 BIOBASE Biological Databases 131
8.26 BioCarta 132
8.27 Biodatabases (AMITA Corporation) 132
8.28 BioDiscovery 133
8.29 Biogen Idec 133
8.30 BioInformatics 134
8.31 BioInformatics Services 135
8.32 BioInformatics Solutions 135
8.33 Biomax Informatics 136
8.34 BioServe Technologies 136
8.35 Biosiris 137
8.36 BioSoftSolutions 137
8.37 Biotique Systems 137
8.38 BioInvent International 138
8.39 Biosite Discovery 138
8.40 BioWa 139
8.41 BioWisdom 139
8.42 Bio-Xtal 140
8.43 Boehringer Ingelheim 140
8.44 Cambridge Antibody Technology Group 141
8.45 Capital Genomix 141
8.46 Celera Group 141
8.47 Cellectis 143
8.48 Cellomics 143
8.49 CeuticalSoft 144
8.50 Chemical Computing Group 145
8.51 Cimarron Software 145
8.52 CLONDIAG Chip Technologies 146
8.53 CodonCode Corporation 146
8.54 CompuDrug International 146
8.55 Compugen USA 147
8.56 Corimbia 148
8.57 Crucell 148
8.58 CSIRO Bioinformatics 149
8.59 CuraGen Corporation 149
8.60 CyberGene 151
8.61 Cytogen 151
8.62 Data Unlimited International 151
8.63 deCODE Genetics 151
8.64 Decodon 152
8.65 Deltagen 152
8.66 Digilab 153
8.67 DNA Software 154
8.68 DNAPrint Genomics 154
8.69 DNA Star 155
8.70 DxS 155
8.71 Dyax Corp. 156
8.72 Eisai 157
8.73 Elan Corporation 157
8.74 Electric Genetics Corporation 159
8.75 Elusys Therapeutics 160
8.76 Entagen 160
8.77 Entelos 160
8.78 Enzon Pharmaceuticals 161
8.79 Epigenomics 162
8.80 ePitope Informatics 163
8.81 EraGen Biosciences 163
8.82 European Bioinformatics Institute (EBI) Industry Programme 163
8.83 Evolutionary BioInformatics 164
8.84 Genamics 164
8.85 GeneData 164
8.86 Gene Logic 165
8.87 Genentech 167
8.88 Geneva Bioinformatics (GeneBio) 168
8.89 Genmab 169
8.90 GenOdyssee 170
8.91 Genolyze 170
8.92 Genomatica 171
8.93 GenomeQuest 171
8.94 Genomic Solutions 172
8.95 Genomining 173
8.96 Genovac 173
8.97 Genzyme 173
8.98 Geospiza 175
8.99 GlaxoSmithKline 176<