The Asian vaccines market is relatively small compared to its population, yet it is growing, and pharmaceutical manufacturers increasingly will look to boost sales from these emerging vaccine markets. The population of nearly 4 billion people throughout Asia accounts for more than half of the global population, yet currently it is Western markets which lead vaccine sales. This hasn't stopped companies from investing in Asian vaccine markets.

The graying of the population in Asia and the growth in some regions such as India and China are primary indicators of the potential for vaccine markets. This has encouraged market participants to increase spending in research and development and distribution facilities in Asian countries. This report examines the market for vaccines used in humans for various types of disease. It covers only commercialized vaccines and developmental vaccines for diseases that are already vaccine-preventable; it does not cover emerging vaccines for diseases that are not currently vaccine-preventable.

As part of its coverage, this report includes:

• Estimated Market Sizes for Pediatric Preventive Vaccines by Type in Asia (Influenz, Hepatitis, HPV, Pneumococcal, Combinations, Other Childhood Diseases)

• Estimated Market Sizes for Adult Preventive Vaccines by Type in Asia (Influenza, Hepatitis, HPV, Travel and Endemic, Others) 2006 - 2014

• Total Vaccine Market and Projections for Asian Countries: India, China, Japan, Korea, Indonesia and Rest of Asia

• Major Manufacturers’ Shares of the Asian Adult Preventive Vaccine Market, 2010

• Profiles of Top Participating Companies

• Discussion of Regulatory Trends and IP Trends

• Disease Statistics and Government Immunization Information

• Manufacturer Strategies in Asian Countries

• Discussion of Current and Emerging Delivery Options Systems

Key issues in the global vaccine market today include product safety, refusal to immunize, supply shortages, the use of vaccines to prevent pandemics and address bioterrorism, and innovations in vaccine delivery systems. Vaccination has played an enormous role in the prevention of disease, having had the greatest impact on human health of any medical intervention. As a result, vaccine-preventable diseases and their resulting deaths are now rare in the developed world. However, developing nations have not benefited as much from the introduction of vaccines. Additionally, other issues such as vaccine safety, shortages and bioterrorism continue to weigh upon the industry.

The following companies are profiled in this report:

• Bavarian Nordic A/S

• Baxter International

• Crucell

• Emergent Biosolutions

• GlaxoSmithKline

• Merck

• Novartis

• Pfizer Inc

• Sanofi Pasteur

• Sinovac Biotech, Ltd

EXECUTIVE SUMMARY

THE ASIAN VACCINES MARKET
Scope and Methodology
Vaccine Overview

Pediatric Preventative Vaccines
Adult Preventative Vaccines

Total Market
Issues and Trends

INTRODUCTION TO VACCINES

Vaccines and The Immune Response
Mechanism of Action
Types of Vaccines

Attenuated (Weakened) Live Viruses
Killed (Inactivated) Viruses
Toxoid Vaccines
Genetically Engineered/Modified Vaccines

Subunit Vaccines
Conjugate Vaccines
DNA Vaccination

Development of Vaccines in Asian Markets
Vaccine Approval Process
 
PEDIATRIC PREVENTIVE VACCINES

Introduction

Vaccine Coverage Rates by Country

China
India
Japan

United Nations Initiatives

Pediatric Vaccine Products

BCG
Diphtheria, Tetanus, Pertussis, Hepatitis B and Polio

Diphtheria
Pertussis
Tetanus
Hepatitis B
Poliomyelitis

Haemophilus Influenzae Type B
Hepatitis A
Human papillomavirus (HPV) vaccination

Gardasil
Cervarix

Measles, Mumps and Rubella

Measles
Mumps
Rubella

Meningococcal Disease
Pneumococcal Conjugate
Rotavirus
Varicella

Pediatric Vaccines in Development
The Asian Market for Pediatric Preventive Vaccines

Total Asian Market Size and Forecast
Asian Market by Product Type

Influenza
Hepatitis A & B
HPV
Childhood Vaccines

Pneumococcal
Combinations
Other Childhood Vaccines

Others

Major Manufacturer’s Market Share—Pediatric Vaccines

ADULT PREVENTIVE VACCINES
Introduction
Adult Vaccine-Preventable Diseases: Facts and Figures
Global Influenza Surveillance Program
Recommendations for Adult Immunizations

WHO International Health Regulations

Adult Vaccine Products

BCG
Cholera
Diphtheria-Tetanus
Hepatitis

Hepatitis A
Hepatitis B

Human Papilloma Virus (HPV)

Gardasil
Cervarix

Influenza

Pandemic Influenza

Avian Flu
Swine Flu

Japanese Encephalitis
Meningitis
Pneumococcal Disease
Rabies
Typhoid Fever
Yellow Fever

Adult Vaccines in Development
The Asian Market for Adult Preventive Vaccines

Total Asian Market Size and Forecast
Asian Market by Product Type

Influenza
Hepatitis
HPV
Travel/Endemic Vaccines
Others

Major Manufacturer’s Market Share—Adult Vaccines

VACCINES MARKET SUMMARY
Trends Driving the Vaccines Market
Market Size and Forecast

Vaccine Sales by Region
Vaccine Market Competitors

ISSUES AND TRENDS
Changes in the Regulatory Structure in Asia-Pacific
Global Immunization Trends
Intellectual Property Concerns
Vaccine Safety

Refusal to Immunize
Obesity
World Health Organization
The Future of Vaccine Safety

Manufacturer Strategies

Acquisitions and Alliances
Access to Medicine Programs
Global Expansion

Manufacturer Risks and Market Inhibitors

Investment Risk in Emerging Growth Markets
Investment Risks for Domestic Chinese Companies
Equitable pricing

Vaccine Shortages

Influenza Vaccine Manufacturing Difficulties
Financial incentives

Preventing Shortages in Developing Nations

Vaccine Bonds

Preventing Pandemics
Vaccines and Bioterrorism

Overview
Smallpox
Tularemia
Viral Hemorrhagic Fevers

DNA Vaccination
Innovations in Vaccine Delivery Systems

Edible Vaccines
Mucosal Delivery
Intranasal Delivery
Vaccine Patches
Vaccine Microneedle Chips

Innovations in Vaccine Production

Plant-Based Production
Insects
Nanoparticle Systems

Variations in Vaccination Schedules and Recommendations

COMPANY PROFILES
Bavarian Nordic A/S

History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information

Baxter International

History and Lines of Business
Vaccine Products
Financial Information

Crucell

History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information

Emergent Biosolutions

History and Lines of Business
Strategic Acquisition and Alliance
Vaccine Products
Financial

GlaxoSmithKline

History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information

Merck

History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information

Novartis

History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information

Pfizer Inc

History and Lines of Business
Vaccine Products
Financial Information

Sanofi Pasteur

History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information

Sinovac Biotech, Ltd

History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information

COMPANY DIRECTORY

List of Exhibits

CHAPTER ONE: EXECUTIVE SUMMARY

Table 1-1: Estimated Market Sizes for Preventive Vaccines by Target Age Group in Asia 2006 - 2014
Figure 1-1: Estimated Market Sizes for Preventive Vaccines in Asian 2006 - 2014 Issues and Trends

CHAPTER TWO: INTRODUCTION TO VACCINES

Table 2-1: Impact of Vaccines in the 20th Century Annual Morbidity in the 20th Century vs 2009 (United States)
Table 2-2: Changes in Preventable Disease Incidence, Japan AnnualIncidence 1985 vs 2008
Table 2-3: Vaccine-Preventable Diseases, June 2010
Table 2-4: Vaccine Research Trials by Region
Figure 2-1: SFDA Drug Approval and Production Approval Processes

CHAPTER THREE: PEDIATRIC PREVENTIVE VACCINES

Table 3-1: Global Immunization Rates by Vaccine Type 2008
Table 3-2: China Immunization Rates by Vaccine Type 1985 and 2008
Table 3-3: India Immunization Rates by Vaccine Type 1985 and 2008
Table 3-4: Japan Immunization Rates by Vaccine Type 1985 and 2008
Table 3-5: Selected Pediatric Vaccines in Development
Table 3-6: Estimated Market Sizes for Pediatric Preventive Vaccines in Asia 2006 - 2014
Table 3-1: Estimated Market Sizes for Pediatric Preventive Vaccines inAsia 2006 - 2014
Table 3-7: Estimated Market Sizes for Pediatric Preventive Vaccines by Type in Asia 2006 - 2014
Figure 3-2: Estimated Market Sizes for Pediatric Preventive Vaccines by Type in Asia, by Percent, 2010
Table 3-8: Major Manufacturers’ Shares of the Pediatric Asian Preventive Vaccine Market, 2010
Figure 3-3: 2010 Asian Pediatric Vaccines Market Share, by Leading Competitors

CHAPTER FOUR: ADULT PREVENTIVE VACCINES

Table 4-1: Recommended Universal Adult Immunization Schedule 2010
Table 4-2: Recommended Adult Immunization Schedule for Populations with Special Medical Conditions, 2010
Table 4-3: WHO Pandemic Classification Schedule
Table 4-4: Cumulative Number of Confirmed Human Cases of Avian Influenza A/(H5N1) Reported to WHO
Table 4-5: Risk for Japanese Encephalitis, by Country1
Table 4-6: Yellow Fever Vaccination Requirements for Travelers to Selected Asian Countries
Table 4-7: Selected Adult Preventive Vaccines in Development, 2010 Selected Adult Preventive Vaccines in Development, 2010
Table 4-8: Estimated Market Sizes for Adult Preventive Vaccinesin Asia 2006 - 2014
Figure 4-1: Estimated Market Sizes for Adult Preventive Vaccines in Asia 2006 - 2014
Table 4-9: Estimated Market Sizes for Adult Preventive Vaccines by Type in Asia 2006 - 2014
Figure 4-2: Estimated Market Sizes for Adult Preventive Vaccines by Typein Asia, by Percent, 2010
Table 4-10: Major Manufacturers’ Shares of the Adult Asian Preventive Vaccine Market, 2010
Figure 4-3: 2010 Asian Adult Vaccines Market Share, byLeading Competitors

CHAPTER FIVE: VACCINES MARKET SUMMARY

Table 5-1: Estimated Market Sizes for Preventive Vaccines by Target Age Group in Asia 2006 - 2014
Table 5-1: Estimated Market Sizes for Preventive Vaccines in Asian 2006 - 2014 111
Figure 5-2: Asian Market for Vaccines Share by Type, 2006, 2010 and 2014
Table 5-2: Estimated Market Sizes for Adult and Pediatric Preventive Vaccines by Asian Region (Japan, China, India, Rest of Asia) 2006 - 2014
Figure 5-3 : Estimated Market Sizes for Adult and Pediatric Preventive Vaccines by Asian Region (Japan, China, India, Rest of Asia) 2006 - 2014
Figure 5-4: Estimated Market Sizes for Adult and Pediatric Preventive Vaccines by Asian Region, by Percent, 2010
Table 5-3: Major Manufacturers’ Shares of the Total Asian Preventive Vaccine Market, 2010
Figure 5-5: 2010 Asian Vaccines Market Share, by Leading Competitors

CHAPTER SIX: ISSUES AND TRENDS

Table 6-1: United Nations Children’s Fund (UNICEF) Indicative Budget Pricing Table for Major Antigens, 2010
Table 6-2: Vaccination Schedules by Selected Country