1. Executive Summary 1.1 Antibacterial Drugs: World Market Review 1.2 Chapter Breakdown 1.3 Research and Analysis Methods
2. An Introduction to Bacteria, Bacterial Infections and Antibacterial Drugs 2.1 Bacteria and Bacterial Infections 2.1.1 Bacteria 2.1.2 Clinically Important Bacteria 2.1.3 Bacterial Infections 2.1.3.1 Bacteria's Infectious Activity 2.2 Antibacterial Drugs 2.2.1 A History of Antibacterial Drugs 2.2.1.1 Penicillin 2.2.1.2 Other Key Steps in the History of Antibacterial Drugs 2.2.2 Mechanisms of Action for Antibacterial Drugs
3. The Antibacterial Drugs Market 2012-2022 3.1 The Antibacterial Drugs Market 2010-2011 3.2 The Antibacterial Drugs Market: Overall Revenue Forecast 2012-2022 3.2.1 Generic Competition 3.2.2 Prescribing Antibacterial Drugs 3.2.3 Bacterial Resistance 3.2.4 R&D Pipeline Will Restrain Growth? 3.3 Cephalosporins Submarket 2010-2011 3.3.1 Cephalosporins Submarket: Revenue Forecast 2012-2022 3.4 Penicillin Submarket 2010-2011 3.4.1 Penicillins Submarket: Revenue Forecast 2012-2022 3.5 Fluoroquinolone Submarket 2010-2011 3.5.1 Fluoroquinolones are Linked with Side Effects 3.5.2 Fluoroquinolone Pipeline 2011 3.5.3 Fluoroquinolone Submarket: Revenue Forecast 2012-2022 3.6 Macrolide Submarket 2010-2011 3.6.1 Dificid: A New Macrolide 3.6.2 Macrolide Submarket: Revenue Forecast 2012-2022 3.7 Carbapenems Submarket 2010-2011 3.7.1 Doribax (Doripenem, Ortho-McNeil/Shionogi) 3.7.2 Carbapenems Submarket: Revenue Forecast 2012-2022 3.8 Other Antibacterial Drugs Submarket 2010-2011 3.8.1 Vibativ 3.8.2 Other Antibacterial Drugs Submarket: Revenue Forecast 2012-2022
4. Leading Antibacterial Drugs: Market Prospects to 2022 4.1 Leading Antibacterial Drugs Overview 4.2 Levaquin 4.2.1 Levaquin: Revenue Forecast 2012-2022 4.3 Zyvox 4.3.1 Zyvox: Revenue Forecast 2012-2022 4.4 Avelox 4.4.1 Avelox: Revenue Forecast 2012-2022 4.5 Augmentin 4.5.1 Augmentin: Revenue Forecast 2012-2022 4.6 Zosyn 4.6.1 Zosyn: Revenue Forecast 2012-2022 4.7 Merrem 4.7.1 Merrem: Revenue Forecast 2012-2022 4.8 Cubicin 4.8.1 Cubicin: US Revenue Forecast 2012-2022 4.9 Primaxin 4.9.1 Primaxin: Revenue Forecast 2012-2022 4.10 Biaxin 4.11 Cravit 4.11.1 Cravit: Revenue Forecast 2012-2022 4.12 Zithromax 4.13 Invanz 4.13.1 Invanz: Revenue Forecast 2012-2022 4.14 Cipro 4.15 Tygacil 4.15.1 Tygacil: Revenue Forecast 2012-2022 4.16 Rocephin 4.16.1 Rocephin: Revenue Forecast 2012-2022 4.17 Zinnat 4.18 Flomox 4.19 Unasyn 4.20 Dalacin C 4.21 Meiact
5. Leading National Antibacterial Drug Markets 2012-2022 5.1 Leading National Markets 2010-2011 5.2 Leading National Markets: Revenue Forecasts 2012-2022 5.3 The European Market: Revenue Forecasts 2012-2022 5.4 The US: Revenues 2012-2022 5.5 China: Revenues 2012-2022 5.6 Japan: Revenues 2012-2022 5.7 India: Revenues 2012-2022 5.8 Brazil: Revenues 2012-2022
6. Antibacterial Drugs R&D Pipeline in 2011 6.1 Zinforo (Ceftaroline, AstraZeneca/Forest Laboratories) 6.2 Ceftobiprole (Basilea Pharmaceutica) 6.3 Restanza (Cethromycin, Advanced Life Sciences): Any Future Development? 6.4 Dalbavancin (Durata Therapeutics) 6.5 Nuvocid (Oritavancin, The Medicines Company) 6.6 TR-701 (Tedizolid, Trius Therapeutics) 6.7 CAZ104 (Ceftazidime/Avibactam, AstraZeneca/Forest Laboratories) 6.7.1 CEF104 (Ceftaroline/Avibactam, AstraZeneca/Forest Laboratories) 6.8 CXA-201 (Cubist) 6.9 NKTR-061 (Amikacin Inhalation, Bayer/Nektar Therapeutics) 6.10 Ramoplanin (Nanotherapeutics) 6.11 Radezolid (Rib-X Pharmaceuticals)
7. Antibacterial Drugs: Industry Trends 2012-2022 7.1 Strengths and Weaknesses in the Antibacterial Drugs Market 2011 7.2 Opportunities and Threats in the Antibacterial Drugs Market 2012-2022 7.3 Late-Stage Pipeline Therapies 7.3.1 Governmental Incentives 7.4 New Strategies 7.4.1. Monoclonal Antibodies 7.4.2 Inhaled Antibiotics for Hospital-Acquired Pneumonia 7.5 Bacterial Resistance: An Opportunity and a Threat 7.5.1 Emerging Resistance 7.5.2 Restricting Drug Use 7.6 The Challenge of Non-Inferiority Trials 7.7 Improved Regulatory Guidance 7.8 Lifecycle Management 7.9 Hospital-Acquired Infections 7.9.1 Treating Hospital-Acquired Infections 7.9.2 Preventing Hospital-Acquired Infections 7.9.3 Hospital Hygiene 7.9.4 Tracking Infections 7.9.5 Advances in Hospital Equipment 7.9.5.1 Copper Kills Bacteria
8. Research Interviews8.1 Professor Malcolm Page, Head of Biology, Basilea Pharmaceutica 8.1 Professor Malcolm Page, Head of Biology, Basilea Pharmaceutica 8.1.1 Basilea Pharmaceutica 8.1.2 Antibacterial Research This Decade 8.1.3 Challenges in Developing Treatments for Gram-Negative Bacteria 8.1.4 Overcoming Drug Resistance 8.1.5 New Targets for Antibacterial Drug Development 8.2 Dr Michael Rudolf, CSO, Kenta Biotech 8.2.1 Kenta Biotech 8.2.2 Monoclonal Antibodies for Bacterial Infections 8.2.3 Challenges in Developing Treatments for Gram-Negative Bacteria 8.2.4 Unmet Needs in the Antibacterial Drugs Market
9. Conclusions from Our Study 9.1 Antibacterial Drugs Market 2012-2022 9.1.1 Leading Product Performance 2012-2022 9.2 The R&D Pipeline: Outlook for the Future 9.3 Bacterial Resistance: a Rising Challenge
Other Content Glossary: Clinical Bacteriology
List of Tables
Table 1.1 Currency Exchange Rates Table 1.2 Common Abbreviations Used in this Report Table 2.1 Common Causes of Hospital-Acquired Infections Worldwide, 2011 Table 2.2 Examples of Clinically-Important Bacteria, 2011 Table 2.3 Mechanism of Action for Leading Antibacterial Drug Classes Table 3.1 Antibacterial Drugs Market by Class, 2010 Table 3.2 Antibacterial Drugs Market: Overall Market and Revenue Forecasts by Class, 2010-2022 Table 3.3 Antibacterial Drugs Market: Drivers and Restraints, 2012-2022 Table 3.4 Antibacterial Drugs: Submarket Shares, 2010-2022 Table 3.5 Cephalosporins Submarket: Drug Revenues, 2010 Table 3.6 Cephalosporins Submarket: Revenue Forecast, 2010-2022 Table 3.7 Cephalosporins Submarket: Drivers and Restraints, 2012-2022 Table 3.8 Penicillins Submarket: Drug Revenues, 2010 Table 3.9 Penicillins Submarket: Drivers and Restraints, 2012-2022 Table 3.10 Penicillins Submarket: Revenue Forecast, 2010-2022 Table 3.11 Fluoroquinolones Submarket: Drug Revenues, 2010 Table 3.12 Penicillins Submarket: Drivers and Restraints, 2012-2022 Table 3.13 Fluoroquinolones Submarket: Revenue Forecast, 2010-2022 Table 3.14 Macrolides Submarket: Drug Revenues, 2010 Table 3.15 Macrolides Submarket: Drivers and Restraints, 2012-2022 Table 3.16 Macrolides Submarket: Revenue Forecast, 2010-2022 Table 3.17 Carbapenems Submarket: Drug Revenues, 2010 Table 3.18 Carbapenems Submarket: Drivers and Restraints, 2012-2022 Table 3.19 Carbapenems Submarket: Revenue Forecast, 2010-2022 Table 3.20 Other Antibacterial Drugs Submarket: Drug Revenues, 2010 Table 3.21 Other Antibacterial Drugs Submarket: Revenue Forecast, 2010-2022 Table 4.1 Top 20 Antibacterial Drugs, 2010 Table 4.2 2010 Top 20 Antibacterial Drugs: Revenue Forecast, 2010-2022 Table 4.3 Levaquin Key Facts, 2011 Table 4.4 Levaquin: Revenue Forecast, 2010-2022 Table 4.5 Zyvox Key Facts, 2011 Table 4.6 Zyvox: Nine-Month Revenue, 2010-2011 Table 4.7 Zyvox: Revenue Forecast, 2010-2022 Table 4.8 Avelox Key Facts, 2011 Table 4.9 Avelox: Six-Month Revenue by Company, 2010-2011 Table 4.10 Avelox: Revenue Forecast, 2010-2022 Table 4.11 Augmentin Key Facts, 2011 Table 4.12 Augmentin: Revenue Forecast, 2010-2022 Table 4.13 Zosyn Key Facts, 2011 Table 4.14 Zosyn: Nine-Month Revenue, 2010-2011 Table 4.15 Zosyn: Revenue Forecast, 2010-2022 Table 4.16 Merrem Key Facts, 2011 Table 4.17 Merrem: Nine-Month Revenue, 2010-2011 Table 4.18 Merrem: Revenue Forecast, 2010-2022 Table 4.19 Cubicin Key Facts, 2011 Table 4.20 Cubicin: Nine-Month Revenue, 2010-2011 Table 4.21 Cubicin: Revenue Forecast, 2010-2022 Table 4.22 Primaxin Key Facts, 2011 Table 4.23 Primaxin: Revenue Forecast, 2010-2022 Table 4.24 Biaxin Key Facts, 2011 Table 4.25 Biaxin: Revenue Forecast, 2010-2022 Table 4.26 Cravit Key Facts, 2011 Table 4.27 Cravit: Revenue, Fiscal Years 2006-2011 Table 4.28 Cravit: Revenue Forecast, 2010-2022 Table 4.29 Zithromax Key Facts, 2011 Table 4.30 Zithromax: Nine-Month Revenue, 2010-2011 Table 4.31 Zithromax: Revenue Forecast, 2010-2022 Table 4.32 Invanz Key Facts, 2011 Table 4.33 Invanz: Six-Month Revenue, 2010-2011 Table 4.34 Invanz: Revenue Forecast, 2010-2022 Table 4.35 Cipro Key Facts, 2011 Table 4.36 Cipro: Revenue Forecast, 2010-2022 Table 4.37 Tygacil Key Facts, 2011 Table 4.38 Tygacil: Nine-Month Revenue, 2010-2011 Table 4.39 Tygacil: Revenue Forecast, 2010-2022 Table 4.40 Rocephin Key Facts, 2011 Table 4.41 Rocephin: Revenue Forecast, 2010-2022 Table 4.42 Zinnat Key Facts, 2011 Table 4.43 Zinnat: Revenue Forecast, 2010-2022 Table 4.44 Flomox Key Facts, 2011 Table 4.45 Flomox: Revenue Forecast, 2010-2022 Table 4.46 Unasyn Key Facts, 2011 Table 4.47 Unasyn: Revenue Forecast, 2010-2022 Table 4.48 Dalacin C Key Facts, 2011 Table 4.49 Dalacin C: Revenue Forecast, 2010-2022 Table 4.50 Meiact Key Facts, 2011 Table 4.51 Meiact: Revenue Forecast, 2010-2022 Table 5.1 Antibacterial Drugs Market by Region, 2010 Table 5.2 Antibacterial Drugs Market: Revenue Forecasts by Region, 2010-2022 Table 5.3 European Antibacterial Drugs Market by Country, 2010 Table 5.4 European Antibacterial Drugs Market: Revenue Forecasts by Country, 2010-2022 Table 6.1 Selected Antibacterial Pipeline Candidates Discussed Table 6.2 Selected Antibacterial Pipeline Candidates Not Discussed Table 7.1 Antibacterial Drugs Market: Strength and Weaknesses, 2011 Table 7.2 Antibacterial Drugs Market: Opportunities and Threats, 2012-2022 Table 7.3 Selected Inhaled Antibiotics in Development, 2011 Table 9.1 Antibacterial Drugs Market: Revenues by Class, 2010, 2016 and 2022 Table 9.2 Fate of the 2010 Top 20 Antibacterial Drugs: Combined Revenues, 2010, 2016 and 2022
List of Figures
Figure 2.1 Milestones in the History of Antibacterial Agents, 1940-2011 Figure 3.1 Antibacterial Drugs: Market Shares by Class, 2010 Figure 3.2 Antibacterial Drugs Market: Overall Market and Revenue Forecasts by Class, 2010-2022 Figure 3.3 Antibacterial Drugs: Market Shares by Class, 2016 Figure 3.4 Antibacterial Drugs: Market Shares by Class, 2022 Figure 3.5 Cephalosporins Submarket: Market Shares, 2010 Figure 3.6 Cephalosporins Submarket: Revenue Forecast, 2010-2022 Figure 3.7 Penicillins Submarket: Market Shares, 2010 Figure 3.8 Penicillins Submarket: Revenue Forecast, 2010-2022 Figure 3.9 Fluoroquinolones Submarket: Market Shares, 2010 Figure 3.10 Fluoroquinolones Submarket: Revenue Forecast, 2010-2022 Figure 3.11 Macrolides Submarket: Market Shares, 2010 Figure 3.12 Macrolides Submarket: Revenue Forecast, 2010-2022 Figure 3.13 Carbapenems Submarket: Market Shares, 2010 Figure 3.14 Carbapenems Submarket: Revenue Forecast, 2010-2022 Figure 3.15 Other Antibacterial Drugs Submarket: Market Shares, 2010 Figure 3.16 Other Antibacterial Drugs Submarket: Revenue Forecast, 2010-2022 Figure 4.1 Top 20 Antibacterial Drugs, 2010 Figure 4.2 2010 Top 20 Antibacterial Drugs: Grouped Revenue Forecast, 2010-2022 Figure 4.3 Levaquin: Revenue Forecast, 2010-2022 Figure 4.4 Zyvox: Nine-Month Revenue, 2010-2011 Figure 4.5 Zyvox: Revenue Forecast, 2010-2022 Figure 4.6 Avelox: Six-Month Revenue by Company, 2010-2011 Figure 4.7 Avelox: Revenue Forecast, 2010-2022 Figure 4.8 Augmentin: Revenue Forecast, 2010-2022 Figure 4.9 Zosyn: Nine-Month Revenue, 2010-2011 Figure 4.10 Zosyn: Revenue Forecast, 2010-2022 Figure 4.11 Merrem: Nine-Month Revenue, 2010-2011 Figure 4.12 Merrem: Revenue Forecast, 2010-2022 Figure 4.13 Cubicin: Nine-Month Revenue, 2010-2011 Figure 4.14 Cubicin: Revenue Forecast, 2010-2022 Figure 4.15 Primaxin: Revenue Forecast, 2010-2022 Figure 4.16 Biaxin: Revenue Forecast, 2010-2022 Figure 4.17 Cravit: Revenue, Fiscal Years 2006-2011 Figure 4.18 Cravit: Revenue Forecast, 2010-2022 Figure 4.19 Zithromax: Nine-Month Revenue, 2010-2011 Figure 4.20 Zithromax: Revenue Forecast, 2010-2022 Figure 4.21 Invanz: Six-Month Revenue, 2010-2011 Figure 4.22 Invanz: Revenue Forecast, 2010-2022 Figure 4.23 Cipro: Revenue Forecast, 2010-2022 Figure 4.24 Tygacil: Nine-Month Revenue, 2010-2011 Figure 4.25 Tygacil: Revenue Forecast, 2010-2022 Figure 4.26 Rocephin: Revenue Forecast, 2010-2022 Figure 4.27 Zinnat: Revenue Forecast, 2010-2022 Figure 4.28 Flomox: Revenue Forecast, 2010-2022 Figure 4.29 Unasyn: Revenue Forecast, 2010-2022 Figure 4.30 Dalacin C: Revenue Forecast, 2010-2022 Figure 4.31 Meiact: Revenue Forecast, 2010-2022 Figure 5.1 Antibacterial Drugs Market Shares by Region, 2010 Figure 5.2 Antibacterial Drugs Market Shares by Region, 2016 Figure 5.3 Antibacterial Drugs Market Shares by Region, 2022 Figure 5.4 European Antibacterial Drugs Market Shares by Country, 2010 Figure 5.5 European Antibacterial Drugs Market: Revenue Forecasts by Country, 2010-2022 Figure 5.6 US Antibacterial Drugs Market: Revenue Forecast, 2010-2022 Figure 5.7 Chinese Antibacterial Drugs Market: Revenue Forecast, 2010-2022 Figure 5.8 Japanese Antibacterial Drugs Market: Revenue Forecast, 2010-2022 Figure 5.9 Indian Antibacterial Drugs Market: Revenue Forecast, 2010-2022 Figure 5.10 Brazilian Antibacterial Drugs Market: Revenue Forecast, 2010-2022 Figure 7.1 Non-Inferiority Trials and Biocreep: A Worst Case Scenario Figure 9.1 Antibacterial Drugs Market: Revenues by Class, 2010, 2016 and 2022 Figure 9.2 Fate of the 2010 Top 20 Antibacterial Drugs: Revenues, 2010, 2016 and 2022
Companies Menstion
Abbott Laboratories Acino Adimab Advanced Life Sciences Agência Nacional de Vigilância Sanitária (Anvisa) [Brazil] Aisling Capital Alliance for the Prudent Use of Antibacterials (APUA) [US] Alopexx Pharmaceuticals Andrx (now part of Watson Pharmaceuticals) APP Pharmaceuticals (a subsidiary of Fresenius Kabi) Arsanis Astellas Pharma AstraZeneca Aurobindo Pharma Barr Pharmaceuticals (now part of Teva) Basilea Pharmaceutica Bayer Bioquell C&O Pharmaceutical Technology (Holdings) Calixa Therapeutics (now part of Cubist Pharmaceuticals) Canaan Partners Cempra Centers for Disease Control and Prevention (CDC) [US] Centers for Medicare and Medicaid Services (CMS) [US] Cipla Copper Development Association [US] Cornerstone Therapeutics Cubist Pharmaceuticals Daiichi Sankyo Dainippon Sumitomo Pharma Dr. Reddy's Laboratories Duke University [US] Durata Therapeutics Eli Lilly EMA Committee for Medicinal Products for Human Use (CHMP) European Medicines Agency (EMA) FDA Anti-Infective Drugs Advisory Committee (AIDAC) [US] Food and Drug Administration (FDA) [US] Forest Laboratories Fresenius Kabi Pharmaceuticals Furiex Pharmaceuticals Future Path Medical Gilead Sciences Glenmark Generics GSK Harvard Medical School Healthcare Infection Control Practices Advisory Committee (HICPAC) [US] Hikma Farmaceutica Hospira Innocell Insmed Itochu Chemical Frontier J&J Janssen Pharmaceutica (a subsidiary of J&J) Japan Patent Office (JPO) KaloBios Pharmaceuticals Kenta Biotech King's College London Lederle Laboratories (acquired by Wyeth, now part of Pfizer) Lupin Pharmaceuticals Medicines and Healthcare products Regulatory Agency (MHRA) [UK] Meiji Seika Kaisha Merck & Co. Michigan State University Ministry of Health and Family Welfare [India] Ministry of Health, Labor and Welfare (MHLW) [Japan] Mpex Pharmaceuticals Mylan Nanotherapeutics National Health Service (NHS) [UK] Nektar Therapeutics New Leaf Venture Partners Novartis Novexel Optimer Pharmaceuticals Orchid Chemicals and Pharmaceuticals Ortho-McNeil Pharmaceuticals (a subsidiary of J&J) Oscient Pharmaceuticals Paratek Pharmaceuticals Parke-Davis (now part of Pfizer) Peking University Pfizer Pharmaceutical Research and Manufacturers of America (PhRMA) [US] Pharmacia (now part of Pfizer) Pliva (now part of Teva) RaQualia Pharma Rib-X Pharmaceuticals Roche Sandoz Sanofi Sanofi Pasteur (part of Sanofi) Sawai Pharmaceutical Schering-Plough (now part of Merck & Co) Shionogi St Thomas' Hospital Strides Arcolab Sumitomo Pharmaceuticals (now part of Dainippon Sumitomo) Takeda Pharmaceutical Company TAP Holdings Targanta Therapeutics (now part of The Medicines Company) Teva Pharmaceuticals The Medicines Company Theravance Trius Therapeutics University of Birmingham [UK] University of Pennsylvania US Department of Defense Vicuron Pharmaceuticals (now part of Durata Therapeutics) Watson Pharmaceuticals Wockhardt World Health Organization (WHO) Wyeth (now part of Pfizer) |