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Sickle Cell Disease Drug Development Pipeline Review, 2017

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Sickle Cell Disease Drug Development Pipeline Review, 2017

Summary

This report provides an overview of the Sickle Cell Disease pipeline landscape. The report provides comprehensive information on the therapeutics under development and key players involved in therapeutic development for sickle cell anemia and vaso-occlusive crisis associated with sickle cell disease, and features dormant and discontinued projects.

Sickle cell anemia is a genetic (inherited) blood disorder in which red blood cells, which carry oxygen around the body, develop abnormally. Signs and symptoms include anemia, delayed growth, vision problems, pain and frequent infections. There are a total of 62 products in development for this indication, by 45 companies and nine academic institutions. Hemoglobin and a range of histone deacetylases are the most common molecular targets being studied in sickle cell anemia.

Vaso-occlusive crisis associated with sickle cell disease is a painful episode that occurs in people who have sickle cell anemia. Symptoms include fever, pain, fatigue, abdominal pain and swelling, headaches, shortness of breath, dehydration and infection. There are a total of 10 products in development for this indication.

Scope

- Which companies are the most active within each pipeline?
- Which pharmaceutical approaches are the most prominent at each stage of the pipeline and within each indication?
- To what extent do universities and institutions play a role within this pipeline, compared to pharmaceutical companies?
- What are the most important R&D milestones and data publications to have happened in this disease area?

Reasons to buy

- Understand the overall pipeline, with an at-a-glance overview of all products in therapeutic development for each indication
- Assess the products in development in granular detail, with an up-to-date overview of each individual pipeline program in each indication, and a comprehensive picture of recent updates and milestones for each
- Analyze the companies, institutions and universities currently operating in the pipeline, and the products being fielded by each of these
- Understand the composition of the pipeline in terms of molecule type, molecular target, mechanism of action and route of administration


1.1 List of Tables 5
1.2 List of Figures 6
2 Introduction 7
2.1 Sickle Cell Disease Report Coverage 7
2.2 Sickle Cell Disease Overview 7
2.3 Vaso-Occlusive Crisis Associated With Sickle Cell Disease Overview 7
3 Therapeutics Development 8
3.1 Sickle Cell Disease 8
3.2 Vaso-Occlusive Crisis Associated With Sickle Cell Disease 15
Therapeutics Assessment 18
.1 Sickle Cell Disease 18
.2 Vaso-Occlusive Crisis Associated With Sickle Cell Disease 25
5 Companies Involved in Therapeutics Development 31
5.1 Sickle Cell Disease 31
5.2 Vaso-Occlusive Crisis Associated With Sickle Cell Disease 7
6 Dormant Projects 52
6.1 Sickle Cell Disease 52
6.2 Vaso-Occlusive Crisis Associated With Sickle Cell Disease 5
7 Discontinued Products 55
7.1 Vaso-Occlusive Crisis Associated With Sickle Cell Disease 55
8 Product Development Milestones 56
8.1 Sickle Cell Disease 56
8.2 Vaso-Occlusive Crisis Associated With Sickle Cell Disease 67
9 Appendix 76
9.1 Methodology 76
9.2 Coverage 76
9.3 Secondary Research 76
9. Primary Research 76
9.5 Expert Panel Validation 76
9.6 Contact Us 77
9.7 Disclaimer 77

List Of Tables

1.1 List of Tables
Table 1: Number of Products under Development for Sickle Cell Disease 8
Table 2: Number of Products under Development by Companies, Sickle Cell Disease 9
Table 3: Number of Products under Development by Universities/Institutes, Sickle Cell Disease 11
Table 4: Products under Development by Companies, Sickle Cell Disease 12
Table 5: Products under Development by Universities/Institutes, Sickle Cell Disease 14
Table 6: Number of Products under Development for Vaso-Occlusive Crisis Associated With Sickle Cell Disease 15
Table 7: Number of Products under Development by Companies, Vaso-Occlusive Crisis Associated With Sickle Cell Disease 16
Table 8: Products under Development by Companies, Vaso-Occlusive Crisis Associated With Sickle Cell Disease 17
Table 9: Number of Products by Stage and Target, Sickle Cell Disease 19
Table 10: Number of Products by Stage and Mechanism of Action, Sickle Cell Disease 21
Table 11: Number of Products by Stage and Route of Administration, Sickle Cell Disease 23
Table 12: Number of Products by Stage and Molecule Type, Sickle Cell Disease 24
Table 13: Number of Products by Stage and Target, Vaso-Occlusive Crisis Associated With Sickle Cell Disease 26
Table 14: Number of Products by Stage and Mechanism of Action, Vaso-Occlusive Crisis Associated With Sickle Cell Disease 27
Table 15: Number of Products by Stage and Route of Administration, Vaso-Occlusive Crisis Associated With Sickle Cell Disease 29
Table 16: Number of Products by Stage and Molecule Type, Vaso-Occlusive Crisis Associated With Sickle Cell Disease 30
Table 17: Sickle Cell Disease Pipeline by Acceleron Pharma Inc 31
Table 18: Sickle Cell Disease Pipeline by Addmedica SAS 31
Table 19: Sickle Cell Disease Pipeline by Angiocrine Bioscience Inc 32
Table 20: Sickle Cell Disease Pipeline by Annexin Pharmaceuticals AB 32
Table 21: Sickle Cell Disease Pipeline by ArQule Inc 33
Table 22: Sickle Cell Disease Pipeline by Bio Products Laboratory Ltd 33
Table 23: Sickle Cell Disease Pipeline by Bioverativ Inc 34
Table 24: Sickle Cell Disease Pipeline by bluebird bio Inc 35
Table 25: Sickle Cell Disease Pipeline by Bristol-Myers Squibb Co 35
Table 26: Sickle Cell Disease Pipeline by Calimmune Inc 36
Table 27: Sickle Cell Disease Pipeline by CRISPR Therapeutics 36
Table 28: Sickle Cell Disease Pipeline by CSL Ltd 37
Table 29: Sickle Cell Disease Pipeline by Daiichi Sankyo Co Ltd 37
Table 30: Sickle Cell Disease Pipeline by Editas Medicine Inc 38
Table 31: Sickle Cell Disease Pipeline by Errant Gene Therapeutics LLC 38
Table 32: Sickle Cell Disease Pipeline by Gamida Cell Ltd 38
Table 33: Sickle Cell Disease Pipeline by Genethon SA 39
Table 34: Sickle Cell Disease Pipeline by Gilead Sciences Inc 39
Table 35: Sickle Cell Disease Pipeline by Global Blood Therapeutics Inc 40
Table 36: Sickle Cell Disease Pipeline by Incyte Corp 40
Table 37: Sickle Cell Disease Pipeline by Ironwood Pharmaceuticals Inc 41
Table 38: Sickle Cell Disease Pipeline by La Jolla Pharmaceutical Company 41
Table 39: Sickle Cell Disease Pipeline by MaxCyte Inc 42
Table 40: Sickle Cell Disease Pipeline by Merck & Co Inc 43
Table 41: Sickle Cell Disease Pipeline by Morphogenesis Inc 43
Table 42: Sickle Cell Disease Pipeline by NKT Therapeutics Inc 43
Table 43: Sickle Cell Disease Pipeline by Novartis AG 44
Table 44: Sickle Cell Disease Pipeline by Orphagen Pharmaceuticals Inc 44
Table 45: Sickle Cell Disease Pipeline by Prolong Pharmaceuticals LLC 45
Table 46: Sickle Cell Disease Pipeline by Protagonist Therapeutics Inc 45
Table 47: Sickle Cell Disease Pipeline by ReveraGen BioPharma Inc 46
Table 48: Sickle Cell Disease Pipeline by Sancilio & Company Inc 46
Table 49: Sickle Cell Disease Pipeline by Sangamo Therapeutics Inc 46
Table 50: Vaso-Occlusive Crisis Associated With Sickle Cell Disease Pipeline by AstraZeneca Plc 47
Table 51: Vaso-Occlusive Crisis Associated With Sickle Cell Disease Pipeline by Bristol-Myers Squibb Co 48
Table 52: Vaso-Occlusive Crisis Associated With Sickle Cell Disease Pipeline by Gilead Sciences Inc 48
Table 53: Vaso-Occlusive Crisis Associated With Sickle Cell Disease Pipeline by Modus Therapeutics Holding AB 49
Table 54: Vaso-Occlusive Crisis Associated With Sickle Cell Disease Pipeline by Novartis AG 49
Table 55: Vaso-Occlusive Crisis Associated With Sickle Cell Disease Pipeline by NuvOx Pharma LLC 50
Table 56: Vaso-Occlusive Crisis Associated With Sickle Cell Disease Pipeline by Pfizer Inc 50
Table 57: Vaso-Occlusive Crisis Associated With Sickle Cell Disease Pipeline by Prolong Pharmaceuticals LLC 51
Table 58: Vaso-Occlusive Crisis Associated With Sickle Cell Disease Pipeline by Seattle Genetics Inc 51
Table 59: Sickle Cell Disease Dormant Projects 52
Table 60: Vaso-Occlusive Crisis Associated With Sickle Cell Disease Dormant Projects 54
Table 61: Vaso-Occlusive Crisis Associated With Sickle Cell Disease Discontinued Products 55

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Reports Details

Published Date : Nov 2017
No. of Pages :77
Country :Global
Category :Pharmaceuticals and Healthcare
Publisher :GBI Research
Report Delivery By :Email
Report Delivery Time :12 to 24 hours after placing the order.

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