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Market Research Reports and Industry Reports

Complete 2017-18 Global Cord Blood Banking Industry Report

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Description
 
 Over the past five years, the global cord blood banking industry has substantially matured and consolidated. This has created both serious threats and novel opportunities for the industry. Serious threats to the industry include low rates of utilization for stored cord blood, expensive cord blood transplantation procedures, difficulty educating obstetricians about cellular therapies, and an increasing trend toward industry consolidation.
 
 Marketing pressures are also impacting the industry, with the term “cord blood” being one of the 20 most expensive search terms on Google. Winning online traffic through Google AdWords for the search phrase “Cord Blood” now costs $45.87 in the U.S. When all locations are allowed, the cost for acquiring online traffic through Google AdWords for the phrase “Cord Blood” is $32.91.
 
 Digital competition for cord blood has also been growing increasingly competitive, with cord blood banks competing for online viewership of ads, website content, and ultimately, clients. Most cord blood banks are using Google Adwords to display advertisements within Google Search as a method of acquiring online visitors. Industry leaders are also publishing enormous quantities of industry-relevant content to dominate in organic (non-paid) online search.
 
 However, there are also emerging opportunities for the industry, such as accelerated regulatory pathways for cell therapies in leading countries worldwide, including the U.S., Japan, and South Korea. Cord blood banks are diversifying into new types of stem cell storage, including cord tissue storage, placental stem cells, amniotic stem cells, menstrual stem cells, adipose tissue, and more.
 
 Holding companies are emerging as a global theme, allowing for increased operational efficiency and economy of scale. Cryoholdco has been acquiring cord blood banks throughout Latin America and Sanpower Group has been purchasing them within Asia. Additionally, growing investment is flowing into cord blood stem cell expansion technologies. Key strategies being explored for this purpose include nicotinamide-mediated (NAM) expansion, Notch ligand, SR-1, UM171, PGE2, and enforced fucosylation. Major market players competing in this space include Gamida Cell Ltd, Nohla Therapeutics, Novartis, Fate Therapeutics, and others.
 
 Finally, growing numbers of investors are entering the cord blood banking marketplace, led by groups such as:
 
 ABS Capital Partners & HLM Management
 KKR & Company
 Bay City Capital
 GTCR, LLC
 Excalibur
 While market factors can vary by geography, it is crucial to have a global understanding of the market. Research advances, clinical trial findings, and technology advances do not know international boundaries. The cord blood market is global in nature and understanding dynamics limited to your region is not sufficient for making strategic, informed, and profitable decisions.
 
 Today, cord blood banks now exist in every developed country, as well as within most developing nations. With approximately 450 companies marketing cord blood banking services worldwide, maturation of the market means that each company is fighting harder for market share. While the U.S. cord blood banking industry is the most mature cord blood banking market in the world, Asia is extremely close behind and growing more quickly than the U.S. market.
 
 In 2016, Sanpower Group and its subsidiary Nanjing Cenbest announced the acquisition of China Cord Blood Corporation (NYSE:CO) and Shandong Cord Blood Bank, positioning it to hold four licenses out of the only seven issued provincial-level cord blood bank licenses in China. According to the company, Sanpower Group has “reserved 800,000 cord blood samples at home, and the associated reserves nearly amount to 1,100,000 when counting in the Cordlife reserves across various Southeast Asian countries and regions.” This positions Sanpower Group and its subsidiary Nanjing Cenbest as the world’s largest cord blood banking operator not only in China and Southeast Asia, but in the world.
 
 Currently, the largest cord blood bank in the United States, Cord Blood Registry, reports to have nearly 700,000 cord blood and tissue units in storage, positioning it substantially behind Sanpower Group. Within China, Sanpower Group reports to control approximately 800,000 cord blood samples. Therefore, Sanpower Group leads CBR by 100,000 units, or 14.2% (800,000 / 700,000 = 1.142), respectively. With CBR controlling more than 50% of the market share in the U.S. and Sanpower Group controlling more than 50% of the market share in China, these two entities are the largest cord blood operators in the world.
 
 Other regions have witnessed major events as well. In 2008, a Taiwanese company, HealthBanks Biotech Company Ltd. became the first company to offer cord tissue storage. It was not until July 2010 that the first private U.S. cord blood bank began offering the service (Cord Blood Registry). Since then, the trend of cord tissue storage has had a major impact on the cord blood banking industry, with a large percentage of cord blood banks offering the service worldwide.
 
 In China, the government shocked the industry by announcing that only one cord blood bank would be allowed to operate within each province, and official government support, authorization, and permits would be required.
 
 In Italy and France, it is illegal to privately store one’s cord blood, which has fully eliminated the potential for a private market to exist within the region.
 
 In Ecuador, the government is now creating the first public cord blood bank and has instituted laws such that private cord blood banks cannot approach women about private cord blood banking options during the first six months of pregnancy. This created a crisis for the private banks, and there are now only two remaining in Ecuador.
 
 Clearly, it is vital to understand market dynamics and risks, as well as the emerging opportunities, within different regions of the world.
 
 This 265 page reports includes:
 
 Market size determinations by market segment
 Trend data for umbilical cord blood grants, patents, and scientific publications
 Clinical trial analysis, including comparison of cord blood vs. cord tissue
 Rates of worldwide cord blood storage (units per year)
 Current and future conditions treatable with cord blood
 Probability of requiring a stem cell transplant by age
 Regulatory pathways affecting cord blood banking in major healthcare markets
 Digital marketing assessment and comparison of industry leaders
 Competitive environment analysis, including identification of market leaders
 Medical opinions of cord blood banking
 Crucial trends and unmet market needs
 And more

I. Abstract
 II. Timeline of Key Events
 III. Technical & Medical Characteristics of Cord Blood
 A. Introduction to Cord Blood and Cord Tissue
 B. Definitions and Nomenclature
 C. Technical Advantages of Cord Blood
 D. Likelihood of Needing a Stem Cell Transplant
 E. Comparison of Cord Blood, Bone Marrow, & Peripheral Blood Stem Cell Transplant
 F. Conditions Treatable with Cord Blood Transplant
 IV. Cord Blood Market Overview
 A. Stem Cell Storage Service Offerings
 B. Public vs. Private Cord Blood Storage
 V. Cord Tissue Market Overview
 A. History of Cord Tissue Storage
 B. Comparison of Cord Blood & Cord Tissue Storage
 C. Clinical Trials Investigating Cord Tissue Derived Mesenchymal Stem Cells (CT-MSCs)
 D. Sources of Mesenchymal Stem Cells
 E. Market Penetration of Cord Tissue Storage within the U.S.
 F. Market Penetration of Cord Tissue Storage Worldwide
 G. Pricing of Cord Tissue Storage (Global Analysis)
 VI. Benefits of Mesenchymal Stem Cells
 A. Key Dates in the Discovery of MSCs
 B. Physical Assessment of MSCs
 C. Benefits of MSCs Relative to Other Stem Cells
 1. Well-Characterized
 2. Non-Controversial
 3. Diverse Differentiation Potential
 4. Ease of Growth in Culture
 5. Flexible Propagation
 6. Clinically Relevant Volumes
 7. Role as Regulatory Cells
 8. Delivery of Gene Products
 9. Favorable Immune Status
 10. Commercially Available Research Tools
 VII. Cord Blood Industry Accreditations
 A. Overview of Cord Blood Industry Accreditation
 B. AABB Accreditation
 VIII. Key Processing Technologies within the Cord Blood Marketplace
 A. AutoXpress® Platform (“AXP®”) and BioArchive System (By Thermogenesis, a Division of Cesca Therapeutics)
 B. Sepax (By Biosafe, in Eysins, Switzerland)
 C. PrepaCyte®-CB (By BioE; Cryo-Cell Purchased Rights in U.S.)
 D. Cord Blood 2.0TM (By Americord)
 E. Other Cord Blood Processing Technologies
 IX. Strategic Collaborations: Key Alliances within the Cord Blood Industry
 A. Cord Blood Registry and Women’s Health Alliance (Largest Women’s Healthcare Groups)
 B. ViaCord and Destination Maternity (Largest Retailer of Maternity Clothing)
 C. Precious Cells Miracle and the Croydon Health Services NHS Trust
 D. CarePilot and “Cord for Life” (Lifeforce Cryobank’s Cord Blood Storage Program)
 E. Cesca Therapeutics and UpState Public Cord Blood Bank
 F. New York Blood Center and Pluristem Therapeutics Collaborate on Adjuvant Therapy for Cord Blood Transplantation
 X. Pairing Cord Blood Banking with Prenatal / Neonatal / Maternal Health Services
 A. Natera, a leader in genetic testing, launches EverCord™ Cord Blood and Tissue Banking Services (March 2017)
 B. ViaCord, owned by PerkinElmer, Launched Newborn Genetic Screening (August 2017)
 C. Human Longevity Inc. Acquired LifeBankUSA (owned by Celgene); LifeBankUSA Passed to Celularity, Inc.
 D. AMAG Pharmaceuticals acquired Cord Blood Registry to Bolster Maternal Health Products (June 2015)
 E. Donor Egg Bank Offers Free Processing of Client’s Newborn Cord Blood through FamilyCord
 XI. Cord Blood Industry Consolidation (Mergers and Acquisitions)
 A. Global Analysis of Mergers & Acquisitions
 B. Role of Holding Companies within the Global Cord Blood Industry
 XII. Technologies for Cord Blood Stem Cell Expansion
 A. Key Strategies for Cord Blood Expansion
 1. NiCord
 2. Notch-1 Ligand
 3. StemRegenin-1 (SR1)
 4. UM171
 5. Enforced Fucosylation
 6. Dimethyl Prostaglandin E2 (PGE2)
 B. Case Study: Gamida Cell Ltd, Industry Leader in Cord Blood Expansion Technology
 XIII. Diversification of Stem Cell Storage Services
 A. Dental Stem Cell Storage
 1. Overview of Dental Stem Cell Storage
 2. Leading Dental Stem Cell Companies
 3. Timeline of Events for Dental Stem Cell Companies
 4. Key Competitors for Dental Stem Cell Storage
 5. BioEden, Leading Provider of Dental Stem Cell Storage Worldwide
 B. Adipose-Derived Stem Cell Storage
 C. Other Types of Stem Cell Storage
 XIV. Comparison of U.S. Cord Blood Market Leaders
 A. Cord Blood Registry
 B. ViaCord
 C. Cryo-Cell International
 D. Comparison of Top 3 Private U.S. Cord Blood Banks
 XV. Comparison of Global Cord Blood Market Leaders
 A. Cryo-Save Group (an Esperite N.V Company)
 B. China Cord Blood Corporation (Owned by Sanpower Group)
 C. LifeCell International
 D. Comparison of International Cord Blood Banks
 XVI. SWOT Analysis for Cord Blood Industry
 A. Strengths
 B. Weaknesses
 C. Opportunities
 D. Threats
 XVII. Regulation of the Cord Blood Marketplace
 A. Regulation of HCT/Ps by the U.S. FDA
 B. 21st Century Cures Act and REGROW Act
 C. Accelerated Approval Pathways for Cell Therapies in Japan
 D. Accelerated Approval Regulator Pathways Worldwide
 XVIII. Trend Rate Analysis
 A. Scientific Publication Rate Analysis
 B. Grant Funding Analysis
 C. Patent Analysis
 D. Clinical Trial Analysis
 E. Market Penetration Rate of Cord Blood Storage
 XIX. Cord Blood Online Marketing Analysis
 A. Cost to Win Online Traffic for the Term “Cord Blood” in Google AdWords
 B. Cost to Win Online Traffic for the Term “Cord Tissue” in Google AdWords
 XX. Key Cord Blood Industry Benchmarks
 A. Medical Society Opinions of Cord Blood Banking
 B. Rates of Parental Awareness
 C. Rates of Worldwide Storage, by Year
 D. Transplant Data
 E. Impact of Haploidentical Transplant
 XXI. Quality Guarantee Comparison
 XXII. Market Size Analysis
 A. Definitions
 B. Methodology
 1. Roll-up All Competitor Sales (“Gold Standard”)
 2. Weighted Analysis of Industry Leaders (“Silver Standard”)
 3. Survey Customers for How Much They Spend in the Market (“Bronze Standard”)
 C. Types of Market Participants
 1. Largest Market Participants
 2. Mid-Sized Market Participants
 3. Small Sized Participants
 4. Public Cord Blood Banking Sector
 5. Summary of Findings
 D. Market Size Determination for Cord Blood and Tissue Banking Market
 E. Market Segmentation for All Applications of Cord Blood and Cord Tissue
 1. Biobanking
 2. Use in Hematopoietic Stem Cell Transplantation (HSCT)
 3. Cellular Therapies
 4. Genetic Manipulation
 5. Research Tools
 F. Market Size Determinations by Market Segment
 XXIII. Cord Blood Industry Leadership
 B. Top Ten Most Influential Cord Blood Banks Worldwide
 1. Cord Blood Registry
 2. ViaCord
 3. Cryo-Cell International
 4. China Cord Blood Corporation (CCBC)
 5. Cryo-Save
 6. Cryoholdco
 7. LifeCell International
 8. Vita34 AG
 9. Crioestaminal
 10. National Cord Blood Program (NCBP) at the New York Blood Center
 XXIV. Global Cord Blood Conferences and Events
 XXV. Investors and Acquisitions Impacting the Global Cord Blood Industry
 A. Investors Impacting the Global Cord Blood Market
 B. Similarities between Acquisition of Cord Blood Registry & ViaCord
 XXV. Geographic Analysis of Evolving Cord Blood Industry Conditions
 A. China
 B. France and Italy
 C. Taiwan
 D. Ecuador
 E. South Africa
 F. Brazil
 XXVI. Summary of Conclusions
 Appendix A –Conditions Treatable with Hematopoietic Stem Cell Transplant (Including Cord Blood Stem Cell Transplant)
 Appendix B – AABB Accredited Cord Blood Banks Worldwide
 Appendix C – List of U.S. Cord Blood Banks by Type of Bank (Private, Hybrid, or Public)
 Appendix D – Global List of Cord Blood Banks Worldwide
  


List Of Tables

TABLE 1. Adulthood Probability of Requiring a Stem Cell Transplant
 TABLE 2. Breakdown of Global Market by Type of Participant
 TABLE 3. Childhood Probability of Requiring a Stem Cell Transplant
 TABLE 4. Clinical Trials Investigating the Use of Cord Tissue Derived Mesenchymal Stem Cells (CT-MSCs)
 TABLE 5. Clinical Trials Underway Involving Use of Wharton’s Jelly, a Rich Source of Cord Tissue MSCs
 TABLE 6. Companies Offering Adipose-Derived Stem Cell Storage (Both Cord Blood Banks and Specialty Companies)
 TABLE 7. Companies Offering Dental Stem Cell Storage, Including Cord Blood Banks and Specialty Companies
 TABLE 8. Comparative Analysis of Pricing Among Leading U.S. Private Cord Blood Banks
 TABLE 9. Comparison of Acquisition of Cord Blood Registry by AMAG Pharmaceuticals and ViaCord by PerkinElmer
 TABLE 10. Comparison of Quality Guarantees Among Private U.S. Cord Blood Banks (Ranked by Value of the Guarantee)
 TABLE 11. Comparison of Services and Features Among Leading Private Cord Blood Banks Worldwide
 TABLE 12. Comparison of Services and Features Among Leading U.S. Private Cord Blood Banks
 TABLE 13. Comparison of Stem Cell Publication Rates by Stem Cell Type
 TABLE 14. Cord Blood Banking Opinions Issued by Medical Societies
 TABLE 15. Cord Blood Clinical Trials Registered at ClinicalTrials.gov
 TABLE 16. Cord Blood Units in the Bone Marrow Donors Worldwide Database
 TABLE 17. Countries Containing AABB Accredited Cord Blood Banks
 TABLE 18. Disease Categories That May Be Treatable with HSCT in the Future
 TABLE 19. Disease Categories Treatable with Hematopoietic Stem Cell Transplantation (HSCT)
 TABLE 20. Esperite N.V. Subsidiaries Operating Worldwide
 TABLE 21. Free Cord Blood Programs for Families in Need in the U.S.
 TABLE 22. Geographic Breakdown of “Cord Blood” Clinical Trials Registered at ClinicalTrials.gov
 TABLE 23. Global Cord Blood Conference and Events
 TABLE 24. Global Private Cord Blood and Tissue Banking Market, by Type of Market Participant
 TABLE 25. Google AdWords Pay-Per-Click Prices for Cord Blood Related Search Terms
 TABLE 26. Industry Investors within the Cord Blood Market
 TABLE 27. Major Acquisitions within the Global Cord Blood Market
 TABLE 28. Market Contribution in USD ($) by Market Segment
 TABLE 29. Market Contribution in USD ($) by Type of Market Participant
 TABLE 30. Market Size Determinations by Market Segment
 TALBE 31. Number of Cord Blood and Tissue Units Stored by Mid-Sized Private Cord Blood Banks
 TABLE 32. Number of Cord Blood and Tissue Units Stored in Largest Private Cord Blood Banks
 TABLE 33. Opportunities within the Global Cord Blood Banking Market
 TABLE 34. Patents Containing “Cord Blood” in the Title or Abstract (Google Patent Search)
 TABLE 35. Percent of Cord Blood Banks Worldwide Offering Cord Tissue Storage Services
 TABLE 36. Percent of Total Global Market by Type of Cord Blood Bank
 TABLE 37. Pricing Structures for Umbilical Cord Tissue
 TABLE 38. Strengths of the Global Cord Blood Banking Market
 TABLE 39. Threats to the Global Cord Blood Banking Market
 TABLE 40. Timeline of Key Events within the Cord Blood Industry
 TABLE 41. Transplants by Cell Source
 TABLE 42. Trend Rate Analysis of Cord Blood and Cord Tissue Scientific Publications
 TABLE 43. Trend Rate Analysis of Cord Blood Grants (RePORTER Tool)
 TABLE 44. Trends in Cord Blood Industry Growth by Geography and Sector
 TABLE 45. Types of Stem Cell Banking
 TABLE 46. Unique Differentiators for CBR, ViaCord, and Cryo-Cell
 TABLE 47. Weaknesses of the Global Cord Blood Banking Market
 TABLE 48: Fetal Sources for Mesenchymal Stem Cell (MSC) Isolation
 TABLE 49: Adult Sources for Mesenchymal Stem Cell (MSC) Isolation
 TABLE 50: Cord Blood Banks Securing Cord Blood Patents as the Assignee


List Of Figures

FIGURE 1. Cord Blood Market Segmentation
 FIGURE 2. Sources of Mesenchymal Stem Cells (MSCs)
 FIGURE 3. Benefits of MSCs Relative to Other Stem Cells
 FIGURE 4. Visualization of “Cord Blood” Clinical Trials (RePORTER Tool)
 FIGURE 5. Comparison of Umbilical Cord Blood vs. Umbilical Cord Tissue
 FIGURE 6. Cord blood treatment options
 FIGURE 7. Cost to Win Online Traffic for Term “Cord Blood” in Google AdWords on a Global Basis
 FIGURE 8. Cost to Win Online Traffic for Term “Cord Blood” in Google AdWords within the U.S.
 FIGURE 9. Density of Research Grants in the U.S. Containing “Cord Blood” in Description
 FIGURE 10. Key Processing Technologies within the Cord Blood Banking Marketplace
 FIGURE 11. Gamida Cell’s Clinical Pipeline Involving Its Cord Blood Derived Products
 FIGURE 12. Geographical Breakdown of “Cord Blood” Clinical Trials Registered at ClinicalTrials.gov
 FIGURE 13. Ground-breaking Years in Transplant History
 FIGURE 14. Key Dates in the Discovery of Mesenchymal Stem Cells
 FIGURE 15. Map of Current Mesenchymal Stem Cell (MSC) Clinical Trials on ClinicalTrials.gov
 FIGURE 16. Search Terms Containing the Phrase “Cord Blood” Within Them (Geography: USA Only)
 FIGURE 17. Leading Landing Page Used by CBR
 FIGURE 18. Common Cryo-Cell Landing Page
 FIGURE 19. Common ViaCord Landing Pages
 FIGURE 20. Technical Advantages of Cord Blood over Bone Marrow or Peripheral Blood
 FIGURE 21. Leading Assignees for Cord Blood Patents
 FIGURE 22. Potential Strategies for Cord Blood Expansion
 GRAPH 1. Likelihood of Requiring a Stem Cell Transplant (From Cord Blood, Bone Marrow, or Peripheral Blood)
 GRAPH 2. # of “Cord Blood” Patents by Country (Title and Abstract Search)
 GRAPH 3. # of Grants Funding Projects with “Cord Blood” in Description (RePORTER Tool)
 GRAPH 4. Breakdown of Global Cord Blood and Tissue Market by Type of Participant
 GRAPH 5. Countries with AABB Accredited Cord Blood Facilities
 GRAPH 6. Market Contributions by Type of Market Participants
 GRAPH 7. Market Contributions by Type of Market Segment
 GRAPH 8. Number of Clinical Trials with “Cord Blood” in the Description
 GRAPH 9. Number of Cord Blood Units in the BMDW Cord Blood Registry, by Year
 GRAPH 10. Percentage of Cord Blood Banks Worldwide Offering Cord Tissue Storage Services
 GRAPH 11. Percentage of Global Market for Cord Blood and Cord Tissue Banking
 GRAPH 12. Registry Transplants by Cell Source
 GRAPH 13. Types of Transplants Used by the 70,000 Patients Requiring Hematopoietic Stem Cell Transplantation Each Year
 GRAPH 14. Year-Over-Year Comparison of Stem Cell Scientific Publications, by Stem Cell Type


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Reports Details

Published Date : Oct 2017
No. of Pages :265
Country :Global
Category :Healthcare
Publisher :BioInformant Worldwide, L.L.C.
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