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Treating Refractory Hematological Malignancies Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML): Emerging Therapeutics

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The report provides an overview of the approved therapies for AML, MDS, unmet need and limitations of the current SOC for relapsed and refractory pts. The report highlights the competition and commercial opportunity in pursuing this therapy area Comprehensive list of the early and late stage drugs in the clinic, their MoA and the companies developing them.

Detailed financial and competitive analysis of the companies leading in the race to launch new therapies for this indication Ambit Biosciences, Onconova Therapeutics, SymBio Pharma, and Celgene are available as a separate or with the full report. Key M&A activities that have taken place in this area in the last 5 years and a list of products in early /late stages of development available for in-licensing are highlighted in the report. This report is built using primary and secondary research data and in-house proprietary database.
Table 1
Refractory MDS/ RR AML: Emerging Therapeutics
REVISED INTERNATIONAL PROGNOSIS SCORING SYSTEM (IPSS-R)
Table 2
Refractory MDS/ RR AML: Emerging Therapeutics
COMPETITIVE LANDSCAPE: RR/ HIGH-RISK MDS AND RR AML
Table 3
Refractory MDS/ RR AML: Emerging Therapeutics
COMPETITIVE LANDSCAPE: UNTREATED/ NEWLY DIAGNOSED MDS AND AML
Table 4
Refractory MDS/ RR AML: Emerging Therapeutics
LAUNCH TIMELINE AND MARKET POTENTIAL
Table 5
Refractory MDS/ RR AML: Emerging Therapeutics
SELECT M&A AND LICENSING DEALS IN LAST 5 YEARS 2007 to 2012
Table 6
Refractory MDS/ RR AML: Emerging Therapeutics
SELECT M&A AND LICENSING DEALS OPPORTUNITIES
Table 7
Ambit Biosciences
NPV VALUATION- Base Case
Table 8
Ambit Biosciences
NPV VALUATION EARLY APPROVAL

Table 9
Ambit Biosciences
COMPETITIVE LANDSCAPE SELECT LATE AND MID STAGE DRUG TARGETING AML
Table 10
Ambit Biosciences
SELECT JAK 2/1 INHIBITORS: MID- TO LATESTAGE PIPELINE
Table 11
Onconova Therapeutics
NPV VALUATION Table 12
Onconova Therapeutics
COMPETITION IN RR MDS/ AML SELECT LATE- TO MID- STAGE COMPOUNDS

List Of Tables

Figure 1
Ambit Biosciences
MONOTHERAPY RESPONSE RATES (CRc) IN AML
Figure 2
Ambit Biosciences
QUIZARITINIB PhIIb COMPARABLE EFFICACY WITH LOWER DOSES
Figure 3
Ambit Biosciences
QTC PROLONGATION AT VARIOUS DOSES OF QUIZARTINIB
Figure 4
Ambit Biosciences
LONG TERM SURVIVORS IN PHASE 2 - TREATED WITH QUIZARTINIB
Figure 5
Ambit Biosciences
QUIZARTINIB MARKET OPPORTUNITY IN US IN AML
Figure 6
Ambit Biosciences
OVERALL SURVIVAL FOR AML PTS LESS THAN 60 YEAR OLD WITH FLT3 ITD MUTATION
Figure 7
Ambit Biosciences
PROPOSED PHIII TRIAL OF QUIZARTINIB
Figure 8
Onconova Therapeutics
PHIII TRIAL DESIGN ONTIME
Figure 9
Onconova Therapeutics
ITT ANALYSIS: SURVIVAL DATA FOR REFRACTORY MDS PTS
Figure 10
Onconova Therapeutics
BEST BONE MARROW (BM) RESPONSES AFTER RIG. IV
Figure 11
Onconova Therapeutics
PHII TRIAL DESIGN ONTARGET
Figure 12
Onconova Therapeutics
PHIII TRIAL DESIGN ONTRAC



List Of Figures

Table 1
Refractory MDS/ RR AML: Emerging Therapeutics
REVISED INTERNATIONAL PROGNOSIS SCORING SYSTEM (IPSS-R)
Table 2
Refractory MDS/ RR AML: Emerging Therapeutics
COMPETITIVE LANDSCAPE: RR/ HIGH-RISK MDS AND RR AML
Table 3
Refractory MDS/ RR AML: Emerging Therapeutics
COMPETITIVE LANDSCAPE: UNTREATED/ NEWLY DIAGNOSED MDS AND AML
Table 4
Refractory MDS/ RR AML: Emerging Therapeutics
LAUNCH TIMELINE AND MARKET POTENTIAL
Table 5
Refractory MDS/ RR AML: Emerging Therapeutics
SELECT M&A AND LICENSING DEALS IN LAST 5 YEARS 2007 to 2012
Table 6
Refractory MDS/ RR AML: Emerging Therapeutics
SELECT M&A AND LICENSING DEALS OPPORTUNITIES
Table 7
Ambit Biosciences
NPV VALUATION- Base Case
Table 8
Ambit Biosciences
NPV VALUATION EARLY APPROVAL

Table 9
Ambit Biosciences
COMPETITIVE LANDSCAPE SELECT LATE AND MID STAGE DRUG TARGETING AML
Table 10
Ambit Biosciences
SELECT JAK 2/1 INHIBITORS: MID- TO LATESTAGE PIPELINE
Table 11
Onconova Therapeutics
NPV VALUATION Table 12
Onconova Therapeutics
COMPETITION IN RR MDS/ AML SELECT LATE- TO MID- STAGE COMPOUNDS

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Reports Details

Published Date : Aug 2013
No. of Pages :37
Country :Global
Category :Healthcare
Publisher :MP Advisors
Report Delivery By :Email
Report Delivery Time :12 to 24 hours after placing the order.

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